Results 231 to 240 of about 72,753 (311)

Temporal Stretch‐Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection

Advanced Science, EarlyView.
Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim, Ji‐Young Yoon, Hwalim Lee, Shanika Karunasagara, Cheng Ji Li, Yongdae Shin, Sukbum Hong, Dong‐Joon Lee, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +10 more
wiley   +1 more source

The Nonlinear and Distinct Responses of Ocean Heat Content and Anthropogenic Carbon to Ice Sheet Freshwater Discharge in a Warming Climate. [PDF]

Earths Future
Gorte T, Lovenduski NS, Nissen C, Lenaerts JTM, Weiss JB.   +4 more
europepmc   +1 more source

A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM)

Advanced Science, EarlyView.
A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri, Adam Nyul‐Toth, Madison Milan, Eva Troyano‐Rodriguez, Sherwin Tavakol, Jennifer Ihuoma, Zeke Reyff, Rakesh Rudraboina, Rafal Gulej, Raymond Jang, Anna Csiszar, Zoltan Ungvari, Audrey Cleuren, David R Miller, Andriy Yabluchanskiy, Mickael Tanter, Stefano Tarantini   +16 more
wiley   +1 more source

The diversity and abundance of chytrids on the Greenland Ice Sheet – new quantitative data

Perini L, Zervas A, Feld L, Jacobsen CS, Benning LG, Tranter M, Anesio AM.   +6 more
europepmc   +1 more source

Plant, insect, and fungi fossils under the center of Greenland's ice sheet are evidence of ice-free times. [PDF]

Proc Natl Acad Sci U S A
Bierman PR, Mastro HM, Peteet DM, Corbett LB, Steig EJ, Halsted CT, Caffee MM, Hidy AJ, Balco G, Bennike O, Rock B.   +10 more
europepmc   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, EarlyView.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

The West Antarctic Ice Sheet may not be vulnerable to marine ice cliff instability during the 21st century. [PDF]

Sci Adv
Morlighem M, Goldberg D, Barnes JM, Bassis JN, Benn DI, Crawford AJ, Gudmundsson GH, Seroussi H.   +7 more
europepmc   +1 more source

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

Advanced Science, EarlyView.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen, Yiming Huang, Yang Zhang, Chunhao Yu, Hanqi Liu, Dong Bian, Di Wu, Wu Wang, Xunming Ji, Yufeng Zheng, Miaowen Jiang, Ming Li   +11 more
wiley   +1 more source

Genetically Engineered Light‐Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen, Jiajia Zhang, Junhan Ou, Ziheng Bai, Tongyan Liu, Kaiyue Zhang, Kaixiang Zhu, James Q. Wang, Chaochen Wang, Qianting Zhang, Linrong Lu, Wenwen Huang   +11 more
wiley   +1 more source

Unlocking Cryogenic Self‐Assembly of Lyotropic Liquid Crystals: A Molecular Perspective From Short‐Range to Long‐Range Scales

Advanced Science, EarlyView.
Cryogenic self‐assembly of lyotropic liquid crystals is achieved using alkyl alkanolamide amphiphiles in a 1,2‐propanediol/water cosolvent system. The hydrocarbon chain length significantly affects the molecular arrangement in bilayers and their long‐range orientational ordering.
Weiluo Guo, Zhenghua Sun, Runxi Wang, Zhuo Zheng, Yubin Ke, Hua Yang, Lingzhi Xie, Yujun Feng, Hongyao Yin   +8 more
wiley   +1 more source