Results 41 to 50 of about 72,753 (311)

Ice sheet model dependency of the simulated Greenland Ice Sheet in the mid-Pliocene [PDF]

Climate of the Past, 2015
Abstract. The understanding of the nature and behavior of ice sheets in past warm periods is important for constraining the potential impacts of future climate change. The Pliocene warm period (between 3.264 and 3.025 Ma) saw global temperatures similar to those projected for future climates; nevertheless, Pliocene ice locations and extents are still ...
Ayako Abe-Ouchi, Ayako Abe-Ouchi, Daniel J. Hill, Daniel J. Hill, Aurélien Quiquet, Aurélien Quiquet, Robert M. DeConto, R. S. W. van de Wal, J. Savage, Fuyuki Saito, Emma J. Stone, David Pollard, Daniel J. Lunt, S. J. Koenig, Aisling M. Dolan, B. de Boer   +15 more
openaire   +9 more sources

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

A stochastic parameterization of ice sheet surface mass balance for the Stochastic Ice-Sheet and Sea-Level System Model (StISSM v1.0) [PDF]

Geoscientific Model Development
Many scientific and societal questions that draw on ice sheet modeling necessitate sampling a wide range of potential climatic changes and realizations of internal climate variability.
L. Ultee, L. Ultee, A. A. Robel, S. Castruccio   +3 more
doaj   +1 more source

Sensitivity of a Greenland ice sheet model to atmospheric forcing fields [PDF]

The Cryosphere, 2012
Predicting the climate for the future and how it will impact ice sheet evolution requires coupling ice sheet models with climate models. However, before we attempt to develop a realistic coupled setup, we propose, in this study, to first analyse the ...
A. Quiquet, H. J. Punge, C. Ritz, X. Fettweis, H. Gallée, M. Kageyama, G. Krinner, D. Salas y Mélia, J. Sjolte   +8 more
doaj   +1 more source

Ice-Sheet Dynamics

Annual Review of Fluid Mechanics, 2013
We describe the development of mathematical models of ice sheets, focusing on underlying physics and the minimal components that successful models must contain. Our review describes the basic fluid dynamical ice-flow models currently in use; points out numerous poorly understood thermomechanical feedbacks in ice flow; and describes the current, often ...
Schoof, C, Hewitt, I
openaire   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Evidence of meltwater retention within the Greenland ice sheet [PDF]

The Cryosphere, 2013
Greenland ice sheet mass losses have increased in recent decades with more than half of these attributed to surface meltwater runoff. However, the magnitudes of englacial storage, firn retention, internal refreezing and other hydrologic processes that ...
A. K. Rennermalm, L. C. Smith, V. W. Chu, J. E. Box, R. R. Forster, M. R. Van den Broeke, D. Van As, S. E. Moustafa   +7 more
doaj   +1 more source

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Climatic Conditions for modelling the Northern Hemisphere ice sheets throughout the ice age cycle [PDF]

Climate of the Past, 2007
The ice sheet-climate interaction as well as the climatic response to orbital parameters and atmospheric CO₂ concentration are examined in order to drive an ice sheet model throughout an ice age cycle.
A. Abe-Ouchi, T. Segawa, F. Saito
doaj