Results 41 to 50 of about 24,049 (264)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction

Advanced Functional Materials, EarlyView.
A programmable interpenetrating double‐network architecture, created via 3D‐TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural rigidity and surface softness—crucial for paediatric laryngeal stents.
Elizabeth F. Maughan, Lei Wu, Dong Zhang, Linxiao Wu, Graca Ferreira Vaz Pinto Mendes, Wanqiao J. Tu, Heping Ma, Toby J. Proctor, Colin R. Butler, Thomas Kjærgaard, Mark W. Lowdell, Martin A. Birchall, Robert E. Hynds, Richard Hewitt, Wenhui Song   +14 more
wiley   +1 more source

Influence of basal melting on ice surface fracture and glacier retreat: A case study at Pine Island Glacier [PDF]

Polish Polar Research
Pine Island Glacier (PIG) is one of the most dynamic ice streams in West Antarctica, with significant basal melting and ice shelf retreat profoundly influencing its behavior.
Boya Yan, Baojun Zhang, Pei Jiang, Qian Li, Yunsi Wu, Mingliang Liu   +5 more
doaj   +1 more source

Past and future dynamics of the Brunt Ice Shelf from seabed bathymetry and ice shelf geometry [PDF]

The Cryosphere, 2019
The recent rapid growth of rifts in the Brunt Ice Shelf appears to signal the onset of its largest calving event since records began in 1915. The aim of this study is to determine whether this calving event will lead to a new steady state in which the ...
D. A. Hodgson, D. A. Hodgson, T. A. Jordan, J. De Rydt, P. T. Fretwell, S. A. Seddon, S. A. Seddon, D. Becker, K. A. Hogan, A. M. Smith, D. G. Vaughan   +10 more
doaj   +1 more source

Frazil ice formation in an ice shelf water plume [PDF]

Journal of Geophysical Research: Oceans, 2004
We present a model for the growth of frazil ice crystals and their accumulation as marine ice at the base of Antarctic ice shelves. The model describes the flow of buoyant water upward along the ice shelf base and includes the differential growth of a range of crystal sizes.
Smedsrud, Lars H., Jenkins, Adrian
openaire   +4 more sources

Laser‐Microscribed Glass Enables Surface‐Microfluidics‐Facilitated, Affordable, Rapid Cancer Diagnosis

Advanced Functional Materials, EarlyView.
A transparent, laser‐microscribed glass platform enables cancer diagnosis within 1 h—much faster than histology, which takes days, and free from the chemical or contrast risks of MRI or CT scans. The antibody‐functionalized rough glass surface captures viable cancer cells directly from suspension, allowing instant optical readout and offering a rapid ...
Anish Pal, Snehasis Mishra, Arani Mukhopadhyay, Ilias Papailias, Atique U. Ahmed, Constantine M. Megaridis   +5 more
wiley   +1 more source

Decadal Variability of Ice‐Shelf Melting in the Amundsen Sea Driven by Sea‐Ice Freshwater Fluxes

Geophysical Research Letters
The ice streams flowing into the Amundsen Sea, West Antarctica, are losing mass due to changes in oceanic basal melting of their floating ice shelves. Rapid ice‐shelf melting is sustained by the delivery of warm Circumpolar Deep Water to the ice‐shelf ...
Michael Haigh, Paul R. Holland
doaj   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Measurements of Ice Shelf Water beneath the front of the Ross Ice Shelf using gliders

Annals of Glaciology, 2017
Measurements made by an underwater glider deployed near the Ross Ice Shelf were used to identify the presence of Ice Shelf Water (ISW), which is defined as seawater with its potential temperature lower than its surface freezing point temperature ...
Monica J.S. Nelson, Bastien Y. Queste, Inga J. Smith, Gregory H. Leonard, Benjamin G.M. Webber, Kenneth G. Hughes   +5 more
doaj   +1 more source

Ekström Ice Shelf, Antarctica [PDF]

Annals of Glaciology, 1988
In 1980–81, 1983–84 and 1985–86 airborne surveys with an electromagnetic reflection (EMR) system were made of Ekström Ice Shelf, Antarctica. The EMR data were supplemented by measurements of surface elevation with radar altimetry during flights at a constant pressure altitude.
F. Thyssen, K. Grosfeld
openaire   +1 more source