Results 91 to 100 of about 1,034,359 (315)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Ice viscosity is more sensitive to stress than commonly assumed

Communications Earth & Environment, 2022
The rate of deformation in Antarctic ice shelves is proportional to stress to the power of 4, not 3 as often used in models, according to a calibration of Glen’s Flow Law with satellite remote sensing data from Antarctic ice shelves.
Joanna D. Millstein, Brent M. Minchew, Samuel S. Pegler   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Change in iceberg calving behavior preceded North Sea ice shelf disintegration during the last deglaciation

Nature Communications
Understanding how regime shifts in iceberg calving behavior affect ice shelf stability remains a challenge for numerical models. This is an important question as we consider the fate of the ice shelves that currently buttress the Antarctic Ice Sheet and ...
James D. Kirkham, Kelly A. Hogan, Robert D. Larter, Neil S. Arnold, Ed Self, Ken Games, Jeremy C. Ely, Chris D. Clark, James D. Scourse, Calvin Shackleton, Jan Erik Arndt, Claus-Dieter Hillenbrand, Mads Huuse, Margaret A. Stewart, Dag Ottesen, Julian A. Dowdeswell   +15 more
doaj   +1 more source

Corrected ICESat altimetry data, surface mass balance, and firn elevation change on Antarctic ice shelves

, 2012
Accurate prediction of global sea-level rise requires that we understand the cause of recent, widespread and intensifying glacier acceleration along Antarctic ice-sheet coastal margins.
Hamish D Pritchard (6967268), Michiel R van den Broeke (6967277), David G Vaughan (7906517), Pritchard, Hamish D, Padman, Laurie, Fricker, Helen, Ligtenberg, Stefan R M, Stefan R M Ligtenberg (6967271), Laurie Padman (6967283), Helen Fricker (6967274), van den Broeke, Michiel R, Vaughan, David G   +11 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Antarctic masks (ice-shelves, ice-sheet, and islands), link to shape file

, 2013
Antarctic masks (ice-shelves, ice-sheet, and islands), link to shape ...
Michiel R van den Broeke (6967277), Mathieu A Depoorter (8004866), Geir Moholdt (6716393), Jan T M Lenaerts (8004872), van den Broeke, Michiel R, Jonathan L Bamber (7969874), Bamber, Jonathan L, Griggs, Jennifer, Jennifer Griggs (8004869), Depoorter, Mathieu A, Ligtenberg, Stefan R M, Stefan R M Ligtenberg (6967271), Lenaerts, Jan T M, Moholdt, Geir   +13 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Bathymetry Beneath Ice Shelves of Western Dronning Maud Land, East Antarctica, and Implications on Ice Shelf Stability

Geophysical Research Letters, 2020
Antarctica's ice shelves play a key role in stabilizing the ice streams that feed them. Since basal melting largely depends on ice‐ocean interactions, it is vital to attain consistent bathymetry models to estimate water and heat exchange beneath ice ...
H. Eisermann, G. Eagles, A. Ruppel, E. Smith, W. Jokat   +4 more
semanticscholar   +1 more source