Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Annual mass budget of Antarctic ice shelves from 1997 to 2021. [PDF]
Sci Adv, 2023 Davison BJ +8 more
europepmc +1 more source
Das Fließen von Schelfeisen - numerische Simulationen mit der Methode der finiten Differenzen (The flow of ice shelves - numerical simulations using the finite-difference method) [PDF]
, 2013 Jürgen Determann
openalex +1 more source
FEBS Open Bio, EarlyView.Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki +3 more
wiley +1 more source
The role of double-diffusive convection in basal melting of Antarctic ice shelves. [PDF]
Proc Natl Acad Sci U S A, 2021 Rosevear MG, Gayen B, Galton-Fenzi BK.
europepmc +1 more source
Theoretical researches into planetary atmospheres and their influence upon surface features [PDF]
The interface between certain geological and atmospheric phenomena on Mars was studied by examining those geological features which are associated with the presence of water in the liquid or solid phases.
Goody, R.
core +1 more source
An analysis of the interaction between surface and basal crevasses in ice shelves
, 2023 Maryam Zarrinderakht +2 more
openalex +1 more source
Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach
FEBS Open Bio, EarlyView.This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma +10 more
wiley +1 more source
Finite Element Analysis of Small Scale Continuous Calving [PDF]
, 2013 Ice shelves are floating ice masses, which are sensitive to climate changes. The main mechanisms for the mass loss of ice shelves around Antarctica are basal melting and calving.
Christmann, Julia +3 more
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