Results 151 to 160 of about 102,620 (291)

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann   +6 more
wiley   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas   +18 more
wiley   +1 more source

The effect of melt-channel geometry on ice-shelf flow

open access: yesJournal of Glaciology
Basal channels are incised troughs formed by elevated melt beneath ice shelves. Channels often coincide with shear margins, suggesting feedbacks between channel formation and shear.
David A. Lilien   +2 more
doaj   +1 more source

The Water Budget in Antarctica [PDF]

open access: yes, 1967
Nearly the whole Antarctic ice sheet, including the attached ice shelves, shows a net accumulation. Factors other than precipitation influence the budget only to a small degree.
F. Loewe
core   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan   +12 more
wiley   +1 more source

Oscillatory response of Larsen C Ice Shelf flow to the calving of iceberg A-68

open access: yesJournal of Glaciology
The collapse of several ice shelves in the Antarctic Peninsula since the late 20th century has resulted in the upstream acceleration of multiple formerly buttressed outlet glaciers, raising questions about the stability of Antarctica's remaining ice ...
Katherine A. Deakin   +3 more
doaj   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez   +12 more
wiley   +1 more source

Ice Velocity Mapping of Ross Ice Shelf, Antarctica by Matching Surface Undulations Measured by Icesat Laser Altimetry [PDF]

open access: yes
We present a novel method for estimating the surface horizontal velocity on ice shelves using laser altimetrydata from the Ice Cloud and land Elevation Satellite (ICESat; 20032009).
Han, Shin-Chan   +4 more
core   +1 more source

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