Results 151 to 160 of about 588,382 (370)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Firn air content changes on Antarctic ice shelves under three future warming scenarios [PDF]
The CryosphereThe Antarctic firn layer provides pore space in which an estimated 94 % to 96 % of the surface melt refreezes or is retained as liquid water. Future depletion of firn pore space by increased surface melt, densification and formation of low-permeability ...
S. B. M. Veldhuijsen +4 more
doaj +1 more source
Theoretical researches into planetary atmospheres and their influence upon surface features [PDF]
The interface between certain geological and atmospheric phenomena on Mars was studied by examining those geological features which are associated with the presence of water in the liquid or solid phases.
Goody, R.
core +1 more source
Feedbacks between ice and ocean dynamics at the West Antarctic Filchner-Ronne Ice Shelf in future global warming scenarios [PDF]
, 2016 The ice flow at the margins of the West Antarctic Ice Sheet is moderated by large ice shelves. Their buttressing effect substantially controls the mass balance of the WAIS and thus its contribution to sea level rise.
Goeller, Sebastian, Timmermann, Ralph
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Brief communication: PICOP, a new ocean melt parameterization under ice shelves combining PICO and a plume model [PDF]
, 2019 Tyler Pelle +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Spatiotemporal change analysis for snowmelt over the Antarctic ice shelves using scatterometers [PDF]
, 2022 Alvarinho J. Luis +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source