Results 21 to 30 of about 1,425,146 (251)

Evidence for the stability of the West Antarctic Ice Sheet divide for 1.4 million years [PDF]

, 2016
Past fluctuations of the West Antarctic Ice Sheet (WAIS) are of fundamental interest because of the possibility of WAIS collapse in the future and a consequent rise in global sea level.
Sugden, David, Stuart, Finlay, Freeman, Stewart, Freeman, Stewart P.H.T., Woodward, John, Marrero, Shasta, Steig, Eric J., Stuart, Finlay M., Westoby, M. J., Westoby, Matt, Sugden, David E., Marrero, Shasta M., Freeman, Stewart P. H. T., Dunning, Stuart, Winter, Kate, Hein, Andrew, Westoby, Matthew J., Hein, Andrew S., Dunning, Stuart A., Steig, Eric, Steig, Eric.J., Hein, Andrew; id_orcid   +21 more
core   +1 more source

Potential subglacial lake locations and meltwater drainage pathways beneath the Antarctic and Greenland ice sheets [PDF]

, 2013
We use the Shreve hydraulic potential equation as a simplified approach to investigate potential subglacial lake locations and meltwater drainage pathways beneath the Antarctic and Greenland ice sheets. We validate the method by demonstrating its ability
Clark, Chris, Woodward, J., Livingstone, Stephen, Woodward, John, Clark, C.D., Kingslake, J., Livingstone, S.J., Livingstone, S. J., Clark, C. D., J. Kingslake, Kingslake, Jonathan, C. D. Clark, S. J. Livingstone, J. Woodward   +13 more
core   +2 more sources

How will melting of ice affect volcanic hazards in the 21st century? [PDF]

, 2010
Glaciers and ice sheets on many active volcanoes are rapidly receding. There is compelling evidence that melting of ice during the last deglaciation triggered a dramatic acceleration in volcanic activity.
Tuffen, Hugh
core   +4 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The Thickness of the Ice in New England in Glacial Times [PDF]

Science, 1883
n ...
openaire   +4 more sources

Hydroelastic Waves in an Ice-Covered Channel with Linearly Varying Ice Thickness

Fluid Dynamics, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Batyaev, E. A., Khabakhpasheva, T. I.
openaire   +3 more sources

Airborne radar evidence for tributary flow switching in Institute Ice Stream, West Antarctica: implications for ice sheet configuration and dynamics [PDF]

, 2015
Despite the importance of ice streaming to the evaluation of West Antarctic Ice Sheet (WAIS) stability we know little about mid- to long-term dynamic changes within the Institute Ice Stream (IIS) catchment.
Martin J. Siegert, Hugh F. J. Corr, Corr, Hugh, Bingham, RG, Woodward, John, Ross, Neil, Ross, N, Dunning, SA, Corr, Hugh F.J., Winter, K, Siegert, MJ, Robert G. Bingham, Winter, Kate, Dunning, Stuart, John Woodward, Neil Ross, Siegert, Martin, Corr, HFJ, Kate Winter, Dunning, Stuart A., Siegert, Martin J., Stuart A. Dunning, Bingham, Robert G., Woodward, J   +23 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source