Results 41 to 50 of about 154,444 (264)

Arctic sea ice variation in the Northwest Passage in 1979–2017 and its response to surface thermodynamics factors

Advances in Climate Change Research, 2021
Sea ice conditions in the Canadian Arctic Archipelago (CAA) play a key role in the navigation of the Northwest Passage (NWP). Limited by observed sea ice thickness data, the research of temporal and spatial variation of sea ice in the NWP is insufficient.
Xin-Yi Shen, Yu Zhang, Chang-Sheng Chen, Song Hu, Dan-Ya Xu, Wei-Zeng Shao, Liang Chang, Gui-Ping Feng   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Influence of Ice Growth Mode on the Ice Thickness and Shape Prediction of Two-Dimensional Airfoil

Aerospace
Computational results of aircraft icing and predictions of ice shape are not only determined by the solutions of air-supercooled droplet two-phase flow and icing thermodynamic models of surface water film, but are also influenced by the growth mode of ...
Xiaobin Shen, Jingyu Zhao, Zekun Ye, Huanfa Wang, Guiping Lin   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Spatiotemporal Analysis and Modeling of Sea Ice Growth Rate in Nella Fjord, Antarctica: Based on Observations During the 36th Chinese National Antarctic Research Expedition in 2020

Frontiers in Environmental Science, 2022
Obtaining field sea ice data is crucial for the validation and improvement of satellite data and numerical models. During the 36th Chinese National Antarctic Research Expedition, seven field observations covering the whole area were conducted in Nella ...
Xiaoyu Sun, Yawen He, Tingting Lv, Chunhua Li, Yi Gao, Fu Zhao, Zhenshan Xue   +6 more
doaj   +1 more source

The Thickness of the Ice in New England in Glacial Times [PDF]

Science, 1883
n ...
openaire   +4 more sources

Hydroelastic Waves in an Ice-Covered Channel with Linearly Varying Ice Thickness

Fluid Dynamics, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Batyaev, E. A., Khabakhpasheva, T. I.
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assimilation of sea-ice concentration in a global climate model – physical and statistical aspects [PDF]

Ocean Science, 2013
We investigate the initialisation of Northern Hemisphere sea ice in the global climate model ECHAM5/MPI-OM by assimilating sea-ice concentration data. The analysis updates for concentration are given by Newtonian relaxation, and we discuss different ways
S. Tietsche, D. Notz, J. H. Jungclaus, J. Marotzke   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source