Results 31 to 40 of about 7,617 (266)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Predictive Skill of a Remote Sensing-Based Machine Learning Model for Ice Wedge and Visible Ground Ice Identification in Western Arctic Canada

Remote Sensing
Fine-scale maps of ground ice and related surface features are critical for permafrost-related modelling and management. However, such maps are lacking across almost the entire Arctic.
Qianyu Chang, Simon Zwieback, Aaron A. Berg   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Effects of ice-wedge degradation and warming on Arctic tundra vegetation across a climatic gradient using a nitrogen-based model

Arctic, Antarctic, and Alpine Research
Ice-wedge polygons in Arctic tundra landscapes influence hydrology, nutrients, thermal regimes, and vegetation. Ice-wedges are particularly vulnerable to warming events, and widespread degradation has been observed in recent decades.
Kelcy Kent, Howard E. Epstein, Lindsay Grose, Mark Torre Jorgenson, Anna Liljedahl   +4 more
doaj   +1 more source

Regional Patterns and Asynchronous Onset of Ice-Wedge Degradation since the Mid-20th Century in Arctic Alaska

Remote Sensing, 2018
Ice-wedge polygons are widespread and conspicuous surficial expressions of ground-ice in permafrost landscapes. Thawing of ice wedges triggers differential ground subsidence, local ponding, and persistent changes to vegetation and hydrologic connectivity
Gerald V. Frost, Tracy Christopherson, M. Torre Jorgenson, Anna K. Liljedahl, Matthew J. Macander, Donald A. Walker, Aaron F. Wells   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

High potential for loss of permafrost landforms in a changing climate

Environmental Research Letters, 2020
The presence of ground ice in Arctic soils exerts a major effect on permafrost hydrology and ecology, and factors prominently into geomorphic landform development.
Olli Karjalainen, Miska Luoto, Juha Aalto, Bernd Etzelmüller, Guido Grosse, Benjamin M Jones, Karianne S Lilleøren, Jan Hjort   +7 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Hydrochemistry of hillslope permafrost catchments with degrading and stable ice-wedge polygons, Ogilvie Mountains, Yukon, Canada

Arctic Science
Ice-wedge polygonal terrain is one of the most widespread landscapes in continuous permafrost, and at many locations, is undergoing substantial degradation.
Emmanuel Carrière, Roxanne Frappier, Jean Bjornson, Denis Lacelle   +3 more
doaj   +1 more source