Results 91 to 100 of about 3,194 (298)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Reconstruction of ice-sheet changes in the Antarctic Peninsula since the Last Glacial Maximum [PDF]

, 2014
This paper compiles and reviews marine and terrestrial data constraining the dimensions and configuration of the Antarctic Peninsula Ice Sheet (APIS) from the Last Glacial Maximum (LGM) through deglaciation to the present day.
Glasser, N.F., Davies, Bethan J., Emma P. Hocking (7190990), Larter, Robert D., Larter, R.D., Anderson, J.B., John B. Anderson (7190993), Livingstone, Stephen J., Simms, A.R., Roberts, S.J., Ó Cofaigh, Colm, Domack, E., Evans, J., Hillenbrand, Claus-Dieter, James A. Smith (1496818), Livingstone, Stephen, Michael J. Bentley (7190996), Livingstone, S.J., Dowdeswell, Julian, Anderson, John B., Hocking, Emma, Eugene Domack (6507515), Anderson, John, Canals, M., Canals, Miquel, Roberts, Stephen J., Johnson, J.S., O Cofaigh, C., Stephen J. Roberts (7191008), Hillenbrand, C.D., Larter, Robert, Simms, Alexander, Neil F. Glasser (7191002), Hodgson, Dominic A., Smith, J.A., Julian A. Dowdeswell (7190999), Bentley, Michael J., Colm O Cofaigh (7190984), Jeffrey Evans (1254507), Dowdeswell, Julian A., Hocking, Emma P., Simms, Alexander R., Hillenbrand, Claus Dieter, Hodgson, D.A., Smith, James A., Bentley, M.J., Domack, Eugene, Dowdeswell, J.A., Davies, Bethan, Alexander R. Simms (7191011), Stephen J. Livingstone (3691018), Joanne S. Johnson (7190987), Robert D. Larter (7191005), Johnson, Joanne S., Bentley, Michael, Hodgson, Dominic, Bethan J. Davies (2843855), Glasser, Neil, Miquel Canals (186525), Claus-Dieter Hillenbrand (4276453), Dominic A. Hodgson (2043412), Evans, Jeffrey, Glasser, Neil F., Hillenbrand, C-D., Canals, Miguel, Hocking, E.P., Davies, B.J.   +66 more
core   +1 more source

Methane and Dissolved Organic Matter in the Ground Ice Samples from Central Yamal: Implications to Biogeochemical Cycling and Greenhouse Gas Emission

Geosciences, 2020
Permafrost thawing leads to mobilization of the vast carbon pool into modern biogeochemical cycling through the enhanced release of dissolved organic matter (DOM) and production of greenhouse gases (CO2 and CH4).
Petr B. Semenov, Anfisa A. Pismeniuk, Sergei A. Malyshev, Marina O. Leibman, Irina D. Streletskaya, Elizaveta V. Shatrova, Alexander I. Kizyakov, Boris G. Vanshtein   +7 more
doaj   +1 more source

Ice Wedge Casts in the Corton Beds [PDF]

Geological Magazine, 1968
The occurrence of casts of ice wedges indicative of a permafrost environment in the Pleistocene Corton beds of Norfolk, England, indicates that deposition of the beds took place in a cold period between the two advances of the Lowestoft glaciation.
openaire   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Stable water isotope data from ice wedges at Kurungnakh [PDF]

, 2017
Stable water isotope data from ice wedges at ...
Meyer, Hanno, Siegert, Christine, Christine Siegert (6961544), Hanno Meyer (6963368), Lutz Schirrmeister (6961397), Grosse, Guido, Guido Grosse (6885275), Schirrmeister, Lutz   +7 more
core   +1 more source

Submarine geomorphology of the northeastern Baffin Island fiords and cross-shelf troughs

Journal of Maps, 2019
This paper presents a series of 50 geomorphological maps of the seabed of northeastern Baffin Island fiords and cross-shelf troughs, in eastern Arctic Canada. The mapping was produced using swath bathymetry imagery from multiple bathymetry datasets.
Etienne Brouard, Patrick Lajeunesse
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

δ18О values in Holocene and modern ice wedges at the Lorino site, Eastern Chukchi Peninsula [PDF]

The oxygen isotope composition (δ18O) of ice wedges sampled in 2015 - 2017 and 2021 was analyzed in the stable isotope laboratory of the Geography Faculty at Lomonosov Moscow State University (Prof. Yu. Vasil'chuk and Dr. N. Budantseva).
Vasil'chuk, Jessica Yurevna, Vasil'chuk, Yurij K, Maslakov, Alexey A, Tokarev, Igor V, Budantseva, Nadine A, Vasil'chuk, Alla Constantinovna   +5 more
core   +1 more source