Results 191 to 200 of about 2,152 (261)

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Allelic variation alters expression and antigen presentation of MR1 allomorphs. [PDF]

J Biol Chem
Nelson AG, Letoga V, Lee CZQ, Samer C, Li S, Meehan LJ, McWilliam HEG, Gherardin NA, Abendroth A, Villadangos JA, Slobedman B, Corbett AJ, McCluskey J, Rossjohn J, Chen Z, Souter MNT, Awad W.   +16 more
europepmc   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Restricting outdoor advertising of unhealthy food: can Australia's food category-based classification system be applied consistently? [PDF]

Health Promot Int
Whitton C, Klug F, Bivoltsis A, Trapp GSA, Pulker CE.   +4 more
europepmc   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

WNT7A/B assemble a GPR124-RECK-LRP5/6 coreceptor complex to activate β-catenin signaling in brain endothelial cells. [PDF]

J Biol Chem
Heiden R, Hannig L, Kuo CJ, Ergün S, Braunger BM, Vallon M.   +5 more
europepmc   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Potential cost-effectiveness of outdoor unhealthy food and drink advertising restrictions in Western Australia. [PDF]

Public Health Nutr
Ananthapavan J, Angeles MR, Groves E, Brown V, Backholer K, Sacks G, Sartori A.   +6 more
europepmc   +1 more source

Towards routine accurate electron-density studies of biological macromolecules. [PDF]

Acta Crystallogr D Struct Biol
Paknia E, Flensburg C, Chodkiewicz ML, Fogh RH, Keller P, Vonrhein C, Schulze-Briese C, Dominiak PM, Bourenkov G, Bricogne G, Chari A.   +10 more
europepmc   +1 more source

Insights from healthy mares reveal that mammalian uteri harbor a diverse virome. [PDF]

Sci Rep
Guo L, Holyoak GR, DeSilva U.
europepmc   +1 more source