Results 51 to 60 of about 23,695 (309)

Numerical modeling of two-dimensional temperature dynamics across ice-wedge polygons [PDF]

, 2017
Thesis (M.S.) University of Alaska Fairbanks, 2017The ice wedges on the North Slope of Alaska have been forming for many millennia, when the ground cracked and the cracks were filled with snowmelt water.
Garayshin, Viacheslav Valer'evich, Гарайшин, Вячеслав Валерьевич   +1 more
core  

Anatomy and origin of authochthonous late Pleistocene forced regression deposits, east Coromandel inner shelf, New Zealand: implications for the development and definition of the regressive systems tract [PDF]

, 2004
High-resolution seismic reflection data from the east Coromandel coast, New Zealand, provide details of the sequence stratigraphy beneath an autochthonous, wave dominated inner shelf margin during the late Quaternary (0-140 ka). Since c.
Bard E., Bard E., Bond G., Bradshaw B. E., Bradshaw B. E., Browne G. H., Chappell J., Chiocci F. L., Dansgaard W., Davis R. A., Emery D., Hart B. S., Haywick D. W., Hernández‐Molina F. J., Hunt D., Hunt D., Kitamura A., Kolla V., Kolla V., Marks G. P., Marshall J. F., Martinson D. G., Mellere D., Mitchum R. M., Morton R. A., Naish T., Nummedal D., Plint A. G., Plint A. G., Plint A. G., Plint A. G., Pomar L., Posamentier H. W., Posamentier H. W., Posamentier H. W., Roy P. S., Roy P. S., Saul G., Schofield J. C., Shackleton N. J., Tesson M. R., Thom B. G., Thom B. G., Thom B. G., Thrasher G. P., Trincardi F., Vail P. R., Van Wagoner J. C., Van Wagoner J. C., Wright I. C., Wright I. C.   +50 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Texture and structure of the Late Holocene ground ice in the Northern West Siberia

Лëд и снег, 2017
The Late Holocene ground ices are occurred due to freeze cracking, slope, thermocast, thermoerosion pro‑ cesses. New formation ice within may intervene to the Pleistocene, lower Holocene ground ice and perma‑ frost and can really complicate their ...
Ya. V. Tikhonravova, E. A. Slagoda, V. V. Rogov, E. I. Galeeva, V. V. Kurchatov   +4 more
doaj   +1 more source

Genetic Identification Of Ground Ice By Petrographic Method

Geography, Environment, Sustainability, 2021
The advantages and limitations of the petrography method and the relevance of its use for the study of natural ice are reviewed in the present work. The petrographic method of ground ice study is often used for solving paleogeographic issues.
Yana V. Tikhonravova, Viktor V. Rogov, Elena A. Slagoda   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Glacigenic debris-flows observed in 3D seismic high-resolution seafloor imagery, Faroe–Shetland Channel, NE Atlantic [PDF]

, 2016
Glacigenic debris-flows represent successive mass-flow deposits that build out a prograding wedge of sediment beyond the grounding zone of an ice sheet (e.g. Laberg & Vorren 1995; King et al. 1998).
Long, D., Stewart, H.A.
core   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An estimate of ice wedge volume for a High Arctic polar desert environment, Fosheim Peninsula, Ellesmere Island [PDF]

The Cryosphere, 2018
Quantifying ground-ice volume on a regional scale is necessary to assess the vulnerability of permafrost landscapes to thaw-induced disturbance like terrain subsidence and to quantify potential carbon release. Ice wedges (IWs) are a ubiquitous ground-ice
C. Bernard-Grand'Maison, W. Pollard
doaj   +1 more source