Results 51 to 60 of about 2,152 (261)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
An estimate of ice wedge volume for a High Arctic polar desert environment, Fosheim Peninsula, Ellesmere Island [PDF]
The Cryosphere, 2018 Quantifying ground-ice volume on a regional scale is necessary to assess the vulnerability of permafrost landscapes to thaw-induced disturbance like terrain subsidence and to quantify potential carbon release. Ice wedges (IWs) are a ubiquitous ground-ice
C. Bernard-Grand'Maison, W. Pollard
doaj +1 more source
Genetic Identification Of Ground Ice By Petrographic Method
Geography, Environment, Sustainability, 2021 The advantages and limitations of the petrography method and the relevance of its use for the study of natural ice are reviewed in the present work. The petrographic method of ground ice study is often used for solving paleogeographic issues.
Yana V. Tikhonravova +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Nonlinear thermal and moisture response of ice-wedge polygons to permafrost disturbance increases heterogeneity of high Arctic wetland [PDF]
Biogeosciences, 2016 Low-center polygonal terrains with gentle sloping surfaces and lowlands in the high Arctic have a potential to retain water in the lower central portion of ice-wedge polygons and are considered high-latitude wetlands.
E. Godin, D. Fortier, E. Lévesque
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Arctic, Antarctic, and Alpine ResearchIce-wedge polygons in Arctic tundra landscapes influence hydrology, nutrients, thermal regimes, and vegetation. Ice-wedges are particularly vulnerable to warming events, and widespread degradation has been observed in recent decades.
Kelcy Kent +4 more
doaj +1 more source
Frontiers in Earth Science, 2021 Global warming, which is especially intensive (up to 0.08°C yr−1) in permafrost area of Central Yakutia, has dramatic consequences for scarce arable land resources in this region.
Roman Desyatkin +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
The Depositional Record, 2019 In the eastern part of the Karoo Basin of South Africa, the sedimentary record of the Late Palaeozoic Ice Age, the Dwyka Group, consists of an up to 200 m thick accumulation of massive to crudely stratified diamictite occasionally interstratified with ...
Pierre Dietrich, Axel Hofmann
doaj +1 more source