Results 211 to 220 of about 35,107 (301)

Cost-effectiveness analysis of chemoradiotherapy compared to surgery in patients with stage I esophageal squamous cell carcinoma in Japan. [PDF]

Int J Clin Oncol
Ariga T, Moriwaki K, Morimoto K, Sakanaka K, Ito Y, Saito T, Katano A, Matsuda S, Kato K, Takeuchi H, Onishi H, Japanese Society for Radiation Oncology (JASTRO) Health Insurance Committee.   +11 more
europepmc   +1 more source

Characterization and Analysis of PHEX Variants in Patients With Hypophosphatemia in Argentina

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Confirming the underlying molecular etiology of hereditary hypophosphatemia (HH) to provide recurrence risk counseling is highly important. Our aims were to describe the detected variants and their distribution across Argentina and to contrast them with published data.
Silvia Ávila, Sara Fernández, Maximiliano Zeballos, María Georgina Poggio   +3 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Cost-effectiveness of early inclisiran for the secondary prevention of cardiovascular disease in Aboriginal and Torres Strait Islander Australians: A Markov modelling analysis. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Hargovan S, Hunt N, Kostakis H, Chow CK.
europepmc   +1 more source

In Vivo Nb4C3Tx MXene‐Assisted Photothermal Therapy of Melanoma in Mice

Advanced NanoBiomed Research, EarlyView.
Nb4C3Tx MXene converts pulsed 1064 nm irradiation into localized heat, producing concentration‐ and time‐dependent melanoma cell killing in vitro and suppressing tumor growth in mice. Histology reveals extensive tumor damage, macrophage‐associated material clearance, and no detectable persistent deposits in examined visceral organs, supporting Nb4C3Tx ...
Anton Roshchupkin, Benjamin Chacon, Gulnaz Gahramanova, Inna Chorna, Zhanna Klishchova, Anastasia Konieva, Ilya Yanko, Andrii Liutyi, Milena Yalyzhko, Ivan Baginskiy, Veronika Zahorodna, Júlio Sílvio de Sousa Bueno Filho, Erfan Rezvani Ghomi, Igor Panko, Tetiana Shapochka, Oksana Sulaieva, Oleksandr Solodovnyk, Lucia Gemma Delogu, Oleksiy Gogotsi, Laura Fusco, Sergiy Kyrylenko, Yury Gogotsi, Maksym Pogorielov   +22 more
wiley   +1 more source

Switching ATP‐Forming Phosphoryl‐Transfer Chemistry With a Restricted Set of Amino Acids

Angewandte Chemie, EarlyView.
Constraints on amino acid composition relevant to prebiotic chemistry reshape enzyme chemistry by replacing the canonical mechanism within a conserved protein fold with a distinct ATP‐forming reaction, ADP disproportionation. Such constraints generate alternative catalytic solutions not observed in modern enzymes and point to chemically plausible early
Sota Yagi, Subrata Dasgupta, Shunsuke Tagami, Satoshi Akanuma   +3 more
wiley   +2 more sources

Economic evaluation of liraglutide versus sitagliptin in the treatment of type 2 diabetes mellitus inadequately controlled with metformin. [PDF]

Front Clin Diabetes Healthc
Yang F, Zheng X, Li W, Zhao Z.
europepmc   +1 more source

Bromide–Borate Coupling Enables Selective Electrochemical Oxidation of Glycerol to Dihydroxyacetone

Angewandte Chemie, EarlyView.
Bromide–borate coupling enables selective electrochemical upgrading of glycerol to dihydroxyacetone (DHA). Electrogenerated bromine species mediate glycerol oxidation, while borate coordination biases selectivity toward DHA, enabling carbon‐balanced oxidation and high productivity in flow‐cell operation.
Santosh Bimli, Pallav Sharma, Dongho Lee
wiley   +2 more sources

Cost, context, and confounding: rethinking real-world data generation and interpretation in advanced NSCLC. [PDF]

Oncologist
Çatlı MM, Önder AH.
europepmc   +1 more source