Results 51 to 60 of about 6,950 (262)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Economic Sustainability of Scrapping Electric and Internal Combustion Vehicles: A Comparative Multiple Italian Case Study

World Electric Vehicle Journal
The transition to sustainable mobility is one of the most pressing and complex challenges for the automotive industry, with impacts that extend beyond the mere reduction of emissions.
Angelo Corallo, Alberto Di Prizio, Mariangela Lazoi, Claudio Pascarelli   +3 more
doaj   +1 more source

Effect of Fuel and Air Dilution on Syngas Combustion in an Optical SI Engine

Energies, 2019
To mitigate the increasing concentration of carbon dioxide in the atmosphere, energy production processes must change from fossil to renewable resources. Bioenergy utilization from agricultural residues can be a step towards achieving this goal.
S.D. Martinez-Boggio, S.S. Merola, P. Teixeira Lacava, A. Irimescu, P.L. Curto-Risso   +4 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Green route to hydrogenation of furfural over Pt-based perovskites: Computational-aided mechanistic elucidation

Results in Chemistry
A catalytically and cost-effective route to hydrogenation of furfural in water over multicationic-perovskites (LaPtxCo1-xO3±δ (0 ≤ ᵡ ≤ 0.25)) is herein presented.
Yamkela Nzuzo, Banele Vatsha, Isaac Beas-Nongwe, Nangamso N. Nyangiwe, Sibongile Pikoli, Ndzondelelo Bingwa   +5 more
doaj   +1 more source

Small area variation in the utilization of common medical tests and consultations in Ontario, Canada

International Journal of Population Data Science, 2017
Objective Evidence of regional variation in the utilization of medical tests and procedures has raised concern surrounding the potential overuse of unnecessary care.
Colleen Webber, Yvonne Dewit, Steve Hall
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Descriptive genomic analysis of antibiotic resistance in Pasteurella multocida isolates from India

Journal of Zoonotic Diseases
Antibiotic resistance in Pasteurella multocida (P. multocida) poses a significant threat to both animal and public health. This study investigates the genomic mechanisms underlying antibiotic resistance in P. multocida strains isolated from various hosts
Umeshkumar Ku , Rekha Karwasra
doaj   +1 more source