Results 61 to 70 of about 86,820 (316)

DC Flashover Performance of Various Types of Ice-Covered Insulator Strings under Low Air Pressure

Energies, 2012
In this study, icing flashover performance tests of typical DC porcelain, glass, and composite insulators are systematically carried out in a multifunction artificial climate chamber.
Lichun Shu, Xingliang Jiang, Daibo Xiao, Jianlin Hu, Caixin Sun, Zhijin Zhang   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Why Spin Ice Obeys the Ice Rules [PDF]

Physical Review Letters, 2005
The low temperature entropy of the the spin ice compounds, such as Ho$_2$Ti$_2$O$_7$ and Dy$_2$Ti$_2$O$_7$, is well described by the nearest-neighbor antiferromagnetic Ising model on the pyrochlore lattice, i.e.\ by the ``ice rules''. This is surprising since the dominant coupling between the spins is their long ranged dipole interaction.
Moessner, R., Sondhi, S. L., Isakov, S. V.   +2 more
openaire   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

AIDER: Aircraft Icing Potential Area DEtection in Real-Time Using 3-Dimensional Radar and Atmospheric Variables

Remote Sensing
Aircraft icing refers to the accumulation of ice on the surface and components of an aircraft when supercooled water droplets collide with the aircraft above freezing levels (at altitudes at which the temperature is below 0 °C), which requires vigilant ...
Yura Kim, Bo-Young Ye, Mi-Kyung Suk
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

NASA's rotorcraft icing research program [PDF]

The objective of the NASA aircraft icing research program is to develop and make available icing technology to support the needs and requirements of industry for all weather aircraft designs.
Miller, Thomas L., Reinmann, John J., Shaw, Robert J.   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A review of research on transmission line icing mechanisms， prediction， and deicing technology

Zhejiang dianli
With the increasing frequency of extreme weather events， transmission line icing disasters pose a growing threat to the safe operation of power grids， making de-icing technology a current research focus. In this context， this paper systematically reviews
ZHAO Wei, PENG WeiYi, ZHOU FeiFan, ZHOU Zhengwei, YANG Tao, WANG Yuanyuan   +5 more
doaj   +1 more source