Results 61 to 70 of about 26,227 (281)
Modeling ice block failure within drift ice and ice rubble
Physical Review E, 2022 A major challenge within material science is the proper modeling of force transmission through fragmenting materials under compression. A particularly demanding material is sea ice, which on small scales is an anisotropic material with quasibrittle characteristics under failure.
Polojärvi, Arttu +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Calculation of impact characteristics and icing phase transitions of salty droplets
Xibei Gongye Daxue XuebaoWhen ships and offshore platforms work in extremely cold and harsh maritime environments, sea spray is the main reason to cause their superstructure to be frozen. In this paper, sea spray is simplified as salty liquid water droplets. Based on the NNW-ICE
TANG Yuhao +3 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
International Journal of Aerospace Engineering, 2023 The ice crystal supercooled droplet mixed phase icing problem is an important research direction in aircraft icing and has received more attention in recent years.
Zhengzhi Wang +4 more
doaj +1 more source
An Experimental Study on Ice Accretion under Bridge Cable in Different Conditions
Applied Sciences, 2023 The ice accumulation on the surface of the stay cable of the bridge is a frequently identified problem that threatens the safety of bridge traffic.
Wentao Li +4 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Methodology to analyse three dimensional droplet dispersion applicable to Icing Wind Tunnels [PDF]
, 2009 This dissertation presents a methodology to simulate the dispersion of water droplets in the air flow typical of an Icing Tunnel. It is based on the understanding the physical parameters that influence the uniformity and the distribution of cloud of ...
Sorato, Sebastiano
core +2 more sources
Results in EngineeringThe chemicals products used in airports are essential to keep air traffic flowing safely and smoothly during winter time. However, there is limited reliable information available regarding both their performance and optimal use. It is therefore essential
Claire Charpentier +3 more
doaj +1 more source