Results 51 to 60 of about 893 (258)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The earliest frescoes in the Church of the Holy Archangel Michael of Tran Monastery [PDF]

Zograf
The results of the most recent restoration of the Monastery of Tran (Western Bulgaria) provide one with an opportunity to reconsider the dating of the two early wall-painting layers in the church. The dome of the naos was the first to be painted.
Kuneva Tsveta
doaj   +1 more source

Ecological Cleaning Systems for Old Icons Painted in Tempera

Chemistry Journal of Moldova, 2014
Old icons, especially those involved in liturgical rituals are affected in time by external agents factors (temperature, humidity, light, pollution, microbiological attack, abrasion etc.), resulting changes of the appearance. Based on the literature in the field, a series of alcoholic solutions of different concentrations were made, as such or basified,
Silvea Pruteanu, Petronela Spiridon, Viorica Vasilache, Ion Sandu   +3 more
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

THE INFLUENCE OF BYZANTIUM ON CHURCH ARCHITECTURE AND ICON PAINTING

Kavkaz-forum, 2022
В статье предпринимается попытка описания различных аспектов византийского влияния на средневековое церковное зодчество и изобразительное искусство (иконопись) аланских храмов, расположенных на территории Северного Кавказа. Анализируются проблемы сохранения этого уникального культурного наследия, а также работа художников-реставраторов, осуществляемая ...
openaire   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Icon in a shining framework in every house. Riza-covered (folezh) icons in Russia at the turn of the 19th and 20th centuries

Studia Humanitatis, 2021
Riza-covered or foil covered (“folezh”) icon with faces and hands painted according to a template decorated with a stamped metal frame became a symbol of the Russian icon painting crisis at the end of the 19th and beginning of the 20th centuries ...
Walczak Dorota
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source