Results 101 to 110 of about 205,210 (292)
Black Bodies as Sacraments of Disruption: Reimagining the Human Person in an Era of Marginalization
ReligionsThe centrality of disruption as a graced moment of awakening social imagination to a new dawn where human flourishing becomes a possibility ought to be the focus of the church’s praxes of sacramental rituals. In fact, Christianity is itself a religion of
SimonMary Asese Aihiokhai
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“Iconoclasm” in the early years of Soviet power (1918–1921) [PDF]
Вестник Свято-Филаретовского институтаThe article is devoted to the struggle against icons, which began literally in the first months after the Bolsheviks came to power. The Bolsheviks themselves called their policy “iconoclasm”.
Rogozny, Pavel G.
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Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
April Fools’ Day, A Celebration of All Things Creative
, 2015 April Fools\u27 Day is unique among our holidays because it is the only one for which ingenuity is required. Other festivals are celebrated with expectations of prepackaged icons.
Gimbel, Steven
core
Comparison of Effective and Non-Effective Icons in the Searching Module Concerning Familiarity and Meaningfulness in Azarakhsh, Simorgh and Nika Digital Libraries [PDF]
کتابداری و اطلاعرسانی, 2016 Purpose: The present study aimed to compare effective and non-effective icons in the searching module with regard to familiarity and meaningfulness in Azarakhsh, Simorgh and Nika digital libraries.
Mahdieh Mirzabegi +2 more
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Constructing Injustice Symbols in Contemporary Trans Rights Activisms
Kvinder, Køn & Forskning, 2019 In this paper, we investigate the role that mourning and commemoration practices play in contemporary trans rights activism. Drawing from visual politics, digital activist culture, as well as media and communication, we analyse how trans rights movements
David Myles, Kelly Lewis
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source