Results 101 to 110 of about 208,085 (307)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Black Bodies as Sacraments of Disruption: Reimagining the Human Person in an Era of Marginalization
ReligionsThe centrality of disruption as a graced moment of awakening social imagination to a new dawn where human flourishing becomes a possibility ought to be the focus of the church’s praxes of sacramental rituals. In fact, Christianity is itself a religion of
SimonMary Asese Aihiokhai
doaj +1 more source
The Social Construction of Perceptual Categories
Journal of Social Ontology, 2022 In this article I shall argue that the categories a subject employs to codify her perceptions are emergent elements of the social niche her community inhabits.
Francesco Consiglio
doaj
“Iconoclasm” in the early years of Soviet power (1918–1921) [PDF]
Вестник Свято-Филаретовского институтаThe article is devoted to the struggle against icons, which began literally in the first months after the Bolsheviks came to power. The Bolsheviks themselves called their policy “iconoclasm”.
Rogozny, Pavel G.
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Composite video and graphics display for camera viewing systems in robotics and teleoperation [PDF]
, 1993 A system for real-time video image display for robotics or remote-vehicle teleoperation is described that has at least one robot arm or remotely operated vehicle controlled by an operator through hand-controllers, and one or more television cameras and ...
Diner, Daniel B., Venema, Steven C.
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The Reception of Aristotle in “On Icons” by St. John Damascene
Forum Theologicum SardicenseThis text will explore Aristotle’s influence on the defense of the veneration of holy images in St. John of Damascus’s Three Apologetic Treatises against Those Decrying the Holy Images.
Alena Kerezova
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source