Results 61 to 70 of about 208,085 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The role of pictures, the veneration of icons and the representation of Christ in two oriental orthodox churches of the Coptic and Ethiopian traditions

Studies in African Languages and Cultures, 2016
The Oriental Orthodox Churches include the Churches of the Coptic and Ethiopian traditions and also of the Syrian and Armenian traditions which will not be mentioned here.
Christine Chaillot
doaj  

Evolution of Symbolisation in Chimpanzees and Neural Nets [PDF]

, 2000
from Introduction: Animal communication systems and human languages can be characterised by the type of cognitive abilities that are required. If we consider the main semiotic distinction between communication using icons, signals, or symbols (Peirce ...
Cangelosi, Angelo
core  

A Chart-Parsing Algorithm for Efficient Semantic Analysis

, 2002
In some contexts, well-formed natural language cannot be expected as input to information or communication systems. In these contexts, the use of grammar-independent input (sequences of uninflected semantic units like e.g. language-independent icons) can
Vaillant, Pascal
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Thefts of icons [PDF]

NBP: Nauka, bezbednost, policija, 2016
The paper first considers certain issues related to the Orthodox icons, and points out to their specific features that differentiate them in relation to any other religious picture.
Samardžić Renata
doaj  

Identifying Continence OptioNs after Stroke (ICONS): an evidence synthesis, case study and exploratory cluster randomised controlled trial of the introduction of a systematic voiding programme for patients with urinary incontinence after stroke in secondary care

Programme Grants for Applied Research, 2015
Background: Urinary incontinence (UI) following acute stroke is common, affecting between 40% and 60% of people in hospital, but is often poorly managed.
Lois H Thomas, Beverley French, Christopher J Sutton, Denise Forshaw, Michael J Leathley, Christopher R Burton, Brenda Roe, Francine M Cheater, Jo Booth, Elaine McColl, Bernadette Carter, Andrew Walker, Katie Brittain, Gemma Whiteley, Helen Rodgers, James Barrett, Caroline L Watkins, on behalf of the ICONS project team and the ICONS patient, public and carer involvement groups   +17 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Investigating familiar interfaces to help older adults learn computer applications more easily [PDF]

, 2011
Many older adults wish to gain competence in using a computer, but many application interfaces are perceived as complex and difficult to use, deterring potential users from investing the time to learn them.
Hollinworth, Nic, Hwang, Faustina
core