Results 51 to 60 of about 677,483 (315)

Empiric Antibiotic Therapy in the Treatment of Community-acquired Pneumonia in a General Hospital in Saudi Arabia [PDF]

, 2019
Background: Guideline-based empiric antimicrobial therapy is recommended for the treatment of community-acquired pneumonia (CAP). In this study, we evaluate the pattern of empiric antibiotics of CAP patients.
Al-Tawfiq, Jaffar A., Hinedi, Kareem, Momattin, Hisham   +2 more
core   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

Presyncope Is Associated with Intensive Care Unit Admission in Emergency Department Patients with Acute Pulmonary Embolism [PDF]

, 2020
Introduction: Syncope is common among emergency department (ED) patients with acute pulmonary embolism (PE) and indicates a higher acuity and worse prognosis than in patients without syncope.
Abraham, Ashley S., Bahl, Disha, Clague, Victoria A., Cotton, Dale M., Engelhart, Darcy C., Huang, Jie, Krauss, William C., Mark, Dustin G., Othieno, Alisha A., Reed, Mary E., Swanson, William P., Vinson, David R.   +11 more
core  

Prognostic robustness of serum creatinine based AKI definitions in patients with sepsis: a prospective cohort study [PDF]

, 2015
Background: It is unclear how modifications in the way to calculate serum creatinine (sCr) increase and in the cut-off value applied, influences the prognostic value of Acute Kidney Injury (AKI).
Dhondt, Annemieke, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond, Vanmassenhove, Jill   +4 more
core   +2 more sources

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Routine Changing of Intravenous Administration Sets Does Not Reduce Colonization or Infection in Central Venous Catheters [PDF]

, 2004
Objective: To determine the effect of routine intravascular administration-set changes on central venous catheter (CVC) colonization and catheter related bacteremia (CRB).
Courtney, Mary, Daley, Peter, Lipman, Jeff, Rickard, Claire, Siversen, Rosemary   +4 more
core   +2 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Automated Measurement of Adherence to Traumatic Brain Injury (TBI) Guidelines using Neurological ICU Data [PDF]

, 2018
Using a combination of physiological and treatment information from neurological ICU data-sets, adherence to traumatic brain injury (TBI) guidelines on hypotension, intracranial pressure (ICP) and cerebral perfusion pressure (CPP) is calculated ...
Moss, Laura, Piper, Ian, Stell, Anthony
core   +1 more source

The Tele-ICU [PDF]

AMA Journal of Ethics, 2014
Telemedicine intensive care units enable off-site physicians to cover many care centers, thereby increasing efficiency and access to care, although their use also raises concerns about varying standards of care, unreliable equipment, the erosion of trust in the patient-physician relationship, and the adequacy of the informed consent process.
Allison, Harriott, Michael A, DeVita
openaire   +2 more sources

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source