Results 61 to 70 of about 677,483 (315)

Association between acute gastrointestinal injury and biomarkers of intestinal barrier function in critically ill patients

open access: yesBMC Gastroenterology, 2017
Background To assess the associations of biomarkers of intestinal barrier function and other clinical variables with acute gastrointestinal injury (AGI) grade, and of these clinical variables with mortality in critically ill patients.
Hongxiang Li   +4 more
doaj   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

open access: yesAdvanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Application of the PDCA cycle for standardized nursing management in sepsis bundles

open access: yesBMC Anesthesiology, 2022
Background To explore the application effect of plan, do, check and action circulation management mode in improving the compliance of sepsis bundle treatment.
Chunxia Liu   +6 more
doaj   +1 more source

Multimodal Needs Assessments for Curricular Refinement – Learner, Expert, EMR [PDF]

open access: yes, 2019
OBJECTIVES •Explore the educational formats and resource preferences of house staff •Identify ICU topics thought to be important by experts in the field •Identify clinically relevant ICU topics •Build an interactive, standardized cognitive aid that ...
Grossman, Catherine
core   +1 more source

Epidemiology of invasive aspergillosis in critically ill patients : clinical presentation, underlying conditions, and outcome [PDF]

open access: yes, 2015
Introduction: Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated a high incidence of IA in intensive care unit (ICU) patients.
Blasco-Navalpotro, Miguel   +13 more
core   +3 more sources

Baptism in the ICU [PDF]

open access: yesThe Linacre Quarterly, 2017
“A swimming pool in the ICU? You must be nuts.”1 The nurse's voice was almost lost amidst the whooshing ventilator and infusion pumps.
openaire   +2 more sources

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15‐Year Retrospective Study from the Largest Children's Hospital in the United States

open access: yesAdvanced Science, EarlyView.
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss   +9 more
wiley   +1 more source

Post-Intensive Care Unit Psychiatric Comorbidity and Quality of Life [PDF]

open access: yes, 2017
The prevalence of psychiatric symptoms ranges from 17% to 44% in intensive care unit (ICU) survivors. The relationship between the comorbidity of psychiatric symptoms and quality of life (QoL) in ICU survivors has not been carefully examined.
Boustani, Malaz   +7 more
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

open access: yesAdvanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi   +15 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

open access: yesAdvanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang   +19 more
wiley   +1 more source

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