Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity. [PDF]
Mancl JM +10 more
europepmc +1 more source
Genetic and clinical investigation of insulin-degrading enzyme in Parkinson's disease within the Chinese Han population. [PDF]
Zheng H +11 more
europepmc +1 more source
Keratinocyte Priming by Staphylococcus aureus Reduces HSV‐1 Susceptibility
ADEH+ patients have a reduced microbial diversity with increased S. aureus and S. epidermidis colonization compared to ADEH− and healthy controls. Heat‐killed S. aureus reduced HSV‐1 susceptibility and release of infectious progeny virus in a keratinocyte in vitro model. Heat‐killed S.
Phila Cara Baumann +19 more
wiley +1 more source
Idecabtagene vicleucel manufacturing and clinical value of out-of-specification products in relapsed and refractory MM. [PDF]
Sidana S +12 more
europepmc +1 more source
Androgen Receptor Expression in Urothelial Bladder Cancer—A Systematic Review and Meta‐Analysis
ABSTRACT Background Bladder cancer is a globally prevalent malignancy with a marked male predominance. Over the past decade, the androgen receptor has been investigated as a potential contributor to bladder cancer pathophysiology. Androgen receptor expression is most commonly assessed via immunohistochemistry, but its association with pathological ...
Alex Buckby +3 more
wiley +1 more source
Decoupling Interfacial Proton Conductivity in Ionomer Thin Films on Pt and Carbon Electrodes. [PDF]
Abe Y +5 more
europepmc +1 more source
In 59,946 chronic hepatitis B patients followed over 23 years, COVID‐19 vaccination rollout was temporally associated with a 56% increase in HBsAg loss rates (peak 1.27 per 100 person‐years in 2022), followed by gradual waning. Negative control outcomes showed no similar pattern, supporting biological specificity. ABSTRACT Background and Aims Hepatitis
Jonggi Choi +6 more
wiley +1 more source
The role of generative AI in collaborative problem‐solving of authentic challenges
Abstract This study investigates undergraduate and postgraduate teamwork in a four‐week ‘Generative AI for Social Good’ hackathon, focusing on how students use GAI tools in authentic problem‐solving within their learning ecology. It examines the factors that foster productive collaboration and explores evidence of AI extending human cognition beyond ...
Nancy Law +7 more
wiley +1 more source
A Perspective for Integrating Real-World Evidence Into the Investigational Device Exemption Study Design for Lumbar Total Joint Replacement. [PDF]
Maislin D +5 more
europepmc +1 more source

