Results 121 to 130 of about 1,365,658 (263)

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, EarlyView.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source

Selective Wettability–Driven Evaporation‐Enhanced Redox Cycling for Robust and Ultrasensitive Detection of Viral Particles

Small Methods, EarlyView.
ABSTRACT Timely detection of viral infections, particularly in settings outside centralized laboratories, is essential for controlling outbreaks. Small electrochemical biosensors are appealing because they are fast, require microliter sample volumes, and can be integrated into portable devices.
Pouya Soltan Khamsi, Shubhada K Chothe, Suresh V Kuchipudi, Aida Ebrahimi   +3 more
wiley   +1 more source

Revealing the Energy Level and Charge Dynamics Interplay in Mixed Pb‐Sn Perovskite Solar Cells with Novel Phenoxazine and Phenothiazine Self‐Assembled Monolayers

Solar RRL, EarlyView.
Carbazole‐based self‐assembled monolayers (SAMs) have proven effective as HTLs in perovskite solar cells (PSCs). However, the energy alignment with narrow‐bandgap lead‐tin (Pb‐Sn) perovskites is suboptimal. Here, we design four phenoxazine/phenothiazine SAMs.
Daniele T. Cuzzupè, Marius Franckevičius, Orestis Karalis, Yekitwork Abebe Temitmie, Mantas Marčinskas, Maria Azhar, Neethinathan Johnee Britto, Timo Eberle, Denis Andrienko, Vytautas Getautis, Tadas Malinauskas, Hannes Hempel, Lukas Schmidt‐Mende   +12 more
wiley   +1 more source

Fragment‐Block: A Novel Approach for Managing Variability in Software Product Lines

Software: Practice and Experience, EarlyView.
ABSTRACT Objective Changes in the functionality of a software product line (SPL) can generate various issues in the SPL source code. Their complexity depends primarily on the amount of changes in the SPL source code and the internal mechanisms for managing variability. Further, modern development frameworks rely on a variety of artefacts besides source
Junior Cupe Casquina, Leonardo Montecchi
wiley   +1 more source

AutoChamber: A broadly accessible 3D‐printed floating chamber to automate measurements of greenhouse gas emissions from surface waters

Methods in Ecology and Evolution, EarlyView.
Abstract Fresh waters provide environmental conditions that favour microbial CO2 and CH4 production, leading to the release of large quantities of greenhouse gases (GHG) to the atmosphere. Despite their importance, these fluxes remain poorly defined, weakening estimates of global GHG budgets that are critical in implementing effective climate ...
Benjamin J. Archer, Peter Casper, Mark O. Gessner   +2 more
wiley   +1 more source

Addiction‐related problems in Japan: A regional perspective

Addiction, EarlyView.
Abstract Japan's addiction landscape appears paradoxical. The lifetime use of illicit drugs is among the lowest in Organisation for Economic Cooperation and Development countries, but harm from alcohol, tobacco, and gambling ranks among the world's highest.
Soichiro Ide, Yoko Nishitani, Masahiko Sumitani, Masabumi Minami, Tadashi Isa, Masako Iseki, Michiko Ohkura, Hitoshi Okamoto, Tetsuro Kikuchi, Yuko Sekino, Hidehiko Takahashi, Kenji Takeuchi, Atsumi Nitta, Takeshi Honjo, Hiroshi Matsumoto, Tsuyoshi Miyakawa, Toshiya Murai, Toshihiko Matsumoto, Kazuyuki Nakagome, Kazutaka Ikeda   +19 more
wiley   +1 more source

Unstable Recompensation: An Intermediate Subtype in Patients With HBV‐Related Decompensated Cirrhosis

Alimentary Pharmacology &Therapeutics, EarlyView.
Recompensation is a heterogeneous and dynamic state in HBV‐related decompensated cirrhosis; The prognosis for patients with unstable recompensation was found to be worse compared to those with stable recompensation, but still better than patients without recompensation; Subclassification of recompensation has significant implications for prognosis and ...
Shuai Xia, Zhiying He, Xiaoning Wu, Zhongjie Hu, Chunqing Zhang, Yanqin Hao, Yongfeng Yang, Yan Huang, Wei Rao, Xiaoqian Xu, Xinyu Zhao, Jialing Zhou, Yameng Sun, Shuyan Chen, Luqi Tang, Xiaojuan Ou, Xinyan Zhao, Jidong Jia, Bingqiong Wang, Hong You   +19 more
wiley   +1 more source

Indocyanine Green Clearance Correlates With Biomarkers Reflecting Key Disease‐Driving Mechanisms in Advanced Chronic Liver Disease and Predicts Acute‐on‐Chronic Liver Failure and Death

Alimentary Pharmacology &Therapeutics, EarlyView.
Indocyanine green clearance by pulse dye densitometry correlates with portal hypertension, systemic inflammation and circulatory dysfunction in advanced chronic liver disease. While diagnostic accuracy for CSPH was limited, ICG‐R15 independently predicted decompensation and ACLF/liver‐related mortality, highlighting its prognostic value across disease ...
Mathias Jachs, Tânia Carvalho, Benedikt Simbrunner, Georg Semmler, Lukas Hartl, Lorenz Balcar, Benedikt Silvester Hofer, Paul Thöne, Nina Dominik, Georg Kramer, Christian Sebesta, Michael Schwarz, David Bauer, Albert F. Stättermayer, Matthias Pinter, Michael Trauner, Thomas Reiberger, Mattias Mandorfer   +17 more
wiley   +1 more source

Hepatitis B Virus RNA Predicts Hepatocellular Carcinoma Despite Viral Suppression

Alimentary Pharmacology &Therapeutics, EarlyView.
Serum HBV RNA levels at viral suppression predict HCC development in nucleos(t)ide analogue‐treated patients with chronic hepatitis B, outperforming Hepatitis B core‐related antigen alone. ABSTRACT Background Despite achieving undetectable hepatitis B virus (HBV) DNA levels with nucleos(t)ide analogue (NA) therapy, patients with chronic hepatitis B ...
Takashi Kumada, Hidenori Toyoda, Satoshi Yasuda, Yuichi Koshiyama, Takanori Ito, Tomoyuki Akita, Junko Tanaka   +6 more
wiley   +1 more source

Dry and Wet Spell Probability by Markov Chain Model for Agricultural Planning at Parbhani

International Journal of Bio-Resource and Stress Management, 2019
Rainfed agriculture plays and will continue to play a dominant role in providing food and livelihoods for an increasing world population. Rainfall analyses are helpful for proper crop planning under changing environment in any region.
P. S. Pawar, U. M. Khodke, A. U. Waikar
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