Transcriptional analysis of landmark molecular pathways in lung adenocarcinoma results in a clinically relevant classification with potential therapeutic implications. [PDF]
We classified lung adenocarcinoma (LUAD) tumors into seven subtypes, based on the transcriptional activity of 50 pathways. Subtypes were associated with distinct molecular and clinical features. Despite significant challenges, we believe that integration of transcriptomic and genomic data may pave the way for guiding novel therapeutic approaches in ...
Hijazo-Pechero S +9 more
europepmc +2 more sources
Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21. [PDF]
Abstract Endosomal trafficking ensures the proper distribution of lipids and proteins to various cellular compartments, facilitating intracellular communication, nutrient transport, waste disposal, and the maintenance of cell structure. Retromer, a peripheral membrane protein complex, plays an important role in this process by recruiting the associated
Romano-Moreno M +3 more
europepmc +2 more sources
Abstract Argyris & Schön's notion of two types of learning, single‐loop (SLL) and double‐loop learning (DLL), is arguably one of the most popularized categorizations of organizational learning (OL). However, while the concept of DLL is widely cited, it has left a superficial impact on the literature and practice. We argue that the limited impact of DLL
Mercedes‐Victoria Auqui‐Caceres +1 more
wiley +1 more source
Characterizing zebra crossing zones using LiDAR data
Abstract Light detection and ranging (LiDAR) scanning in urban environments leads to accurate and dense three‐dimensional point clouds where the different elements in the scene can be precisely characterized. In this paper, two LiDAR‐based algorithms that complement each other are proposed.
Alberto M. Esmorís +5 more
wiley +1 more source
The Genetic Basis of Cognitive Impairment and Dementia in Parkinson's Disease. [PDF]
Cognitive dysfunction is a common feature of Parkinson's disease (PD) with mild cognitive impairment affecting around a quarter of patients in the early stages of their disease, and approximately half developing dementia by 10 years from diagnosis ...
Collins, Lucy M +1 more
core +2 more sources
Formación de burbujas financieras y crisis: de la crisis del Nasdaq a la crisis de la hipotecas subprime [PDF]
A partir de dos burbujas recientes, la de los valores tecnológicos, NASDAQ, y la actual burbuja de la deuda se pone énfasis en los problemas de valoración y medición de los riesgos financieros y en los errores de la regulación y supervisión financieras ...
Vilariño, Ángel
core +1 more source
ABSTRACT Food waste is a sustainability concern in the food industry, which can be mitigated through a circular economy. Circularity can be limited by contextual constraints, such as the characteristics of the waste to be recovered. However, their study in the context of food waste is scarce.
Stella Viscardi +2 more
wiley +1 more source
ABSTRACT This paper tackles one key limitation in the analysis of Iron Age communities in the Northwestern Iberian Peninsula: the limited exploration of areas beyond the fortified settlements known as castros (hillforts). The vast majority of archaeological studies have focused exclusively on the areas inside the walls of these settlements, which are ...
César Parcero‐Oubiña +7 more
wiley +1 more source
Un recorregut bibliogràfic sobre les relacions entre literatura i tecnologia. Un estat de la qüestió a la universitat espanyola [PDF]
Malgrat l'habitual reticència dels departaments d'estudis literaris de les universitats espanyoles a incorporar la reflexió sobre la novetat, conceptual i tecnològica, que ha significat l'aparició de noves formes d'expressió vinculades a l'ordinador i a ...
Adell Pitarch, Joan-Elies
core
La crisis del euro. Una reflexión sobre las políticas de austeridad y el diseño institucional de la Unión Económica y Monetaria Europea [PDF]
La crisis del euro se ha analizado con profusión desde que, con el rescate a Grecia a principios de 2010, la Unión Económica y Monetaria (UEM) europea impuso unas políticas de austeridad muy severas a un conjunto de países periféricos. La singularidad de
Oyarzun de la Iglesia, Francisco Javier
core +2 more sources

