Results 31 to 40 of about 1,273,243 (249)

El vértigo de la filosofía

open access: yesTheoría Revista del Colegio de Filosofía, 2010
Este ensayo es una interpretación de Filosofía del futuro de Eugenio Trías como una propuesta de pensamiento trágico contemporáneo. Para ello, el autor, amparándose en la noción de viaje trágico, desarrolla la concepción del devenir como reiteración ...
Crescenciano Grave
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Desilusão: Impasses Clínicos e Políticos diante dos Dilemas de nosso Tempo

open access: yesRevista Subjetividades, 2018
Acontecimentos sociais e políticos, nacionais e internacionais, têm abalado nosso cotidiano. Conquistas que pareciam sedimentadas na direção da democracia e nos temas relativos aos direitos humanos, conquistas sociais e considerações éticas na vida ...
Miriam Debieux Rosa   +2 more
doaj   +1 more source

Comprehension of creativity in the context of the correlation of Plato’s philosophy, theories of fractals and archetypes

open access: yesCreativity Studies, 2022
The study examines the creative process using the logical and methodological analysis of Plato’s concepts. It presents the modern scientific research related directly or indirectly to his philosophical views (the structural analogy method, the theory of ...
Anatoliy Stoletov
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Números y significaciones. La idealidad en la fenomenología incipiente de Husserl

open access: yesAnales del Seminario de Historia de la Filosofía, 2017
La reflexión sobre los números y las significaciones es una buena muestra de cómo la fenomenología incipiente se sitúa en el terreno de la lógica pura. El artículo plantea que, para trazar una reflexión que no rasgue la personalidad filosófica de Husserl,
José Manuel Chillón
doaj   +1 more source

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