Results 41 to 50 of about 21,645 (263)
An ideal model for recursive polymorphic types
Information and Control, 1984 The paper presents a construction of a model for polymorphic recursive types which extend the type system of \textit{D. B. MacQueen} and \textit{R. Sethi} [(*)\ ``A higher order polymorphic type system for applicative languages'', Symp. LISP Functional Programming, Pittsburgh, 1982, 243- 252].
David B. MacQueen +2 more
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Frontiers in Marine Science, 2023 When the barotropic tide encounters variable bathymetry, fluctuating flow along a topographic slope generates baroclinic tides, or internal tides. There is growing evidence that these internal tides can affect primary production in the euphotic zone ...
Jasen R. Jacobsen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Geophysical Research LettersIn response to rising CO2, chemistry‐climate models (CCMs) project that extratropical stratospheric ozone will increase, except around 10 and 17 km. We call the muted increases or reductions at these altitudes the “double dip.” The double dip results ...
Aaron Match, Edwin P. Gerber
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
Applied Sciences, 2020 Simulation of the human body normal operating conditions is the important issue in the engineering process of designing biomedical devices intended for implantation.
Andrey Porfiryev +6 more
doaj +1 more source