Results 51 to 60 of about 26,011 (307)

Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids [PDF]

, 2011
The nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission in the brain and peripheral nervous system.
Shanata, Jai Anand Pattur
core   +1 more source

An ideal model for recursive polymorphic types

Information and Control, 1984
The paper presents a construction of a model for polymorphic recursive types which extend the type system of \textit{D. B. MacQueen} and \textit{R. Sethi} [(*)\ ``A higher order polymorphic type system for applicative languages'', Symp. LISP Functional Programming, Pittsburgh, 1982, 243- 252].
David B. MacQueen, Gordon D. Plotkin, Ravi Sethi   +2 more
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

A numerical study of laterally strained wall-bounded turbulence

, 2009
Direct numerical simulation (DNS) is used to study the effects of mean lateral divergence and convergence on wall-bounded turbulence, by applying uniform irrotational temporal deformations to a plane-channel domain.
Coleman, G.N., Spalart, P.R., Kim, J., Fedorov, D.   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Modeling an idealized Moist Atmosphere (MiMA) v0.1

, 2015
Model of an idealized Moist Atmosphere: Intermediate-complexity General Circulation Model with interactive water vapor and full radiation. Still under heavy development, this model has been used by Martin Jucker for generating results for the American ...
Martin Jucker (694008)
core   +1 more source

Nutricline adjustment by internal tidal beam generation enhances primary production in idealized numerical models

Frontiers in Marine Science, 2023
When the barotropic tide encounters variable bathymetry, fluctuating flow along a topographic slope generates baroclinic tides, or internal tides. There is growing evidence that these internal tides can affect primary production in the euphotic zone ...
Jasen R. Jacobsen, Christopher A. Edwards, Brian S. Powell, John A. Colosi, Jerome Fiechter   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The Double Dip: How Tropospheric Expansion Counteracts Increases in Extratropical Stratospheric Ozone Under Global Warming

Geophysical Research Letters
In response to rising CO2, chemistry‐climate models (CCMs) project that extratropical stratospheric ozone will increase, except around 10 and 17 km. We call the muted increases or reductions at these altitudes the “double dip.” The double dip results ...
Aaron Match, Edwin P. Gerber
doaj   +1 more source