Results 51 to 60 of about 839,014 (230)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Transformations of the historical context in the linguistic consciousness: Ideas, idols, and ideals
Ученые записки Казанского университета: Серия Гуманитарные науки, 2017 The present paper is of high relevance, because this year marks the 100th anniversary of the events of 1917, which forces us to reconsider the situation of that time.
M.A. Pilgun
doaj
ON HYBRID INTERIOR IDEALS IN SEMIGROUPS
Проблемы анализа, 2019 In this paper, we introduce the notion of hybrid interior ideals and hybrid characteristic interior ideals of a semigroup. We obtain some equivalent conditions for a hybrid structure to be a hybrid interior ideal of a semigroup.
K. Porselvi, B. Elavarasan
doaj +1 more source
The Differential Dimension Polynomial for Characterizable Differential Ideals [PDF]
, 2014 We generalize the differential dimension polynomial from prime differential ideals to characterizable differential ideals. Its computation is algorithmic, its degree and leading coefficient remain differential birational invariants, and it decides ...
Lange-Hegermann, Markus
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Insertion Systems Controlled by Ideals and Codes [PDF]
Computer Science Journal of MoldovaWe study the generative power of controlled insertion systems where the control languages are special codes or ideals instead of arbitrary regular languages.
Jurgen Dassow, Bianca Truthe
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source