Results 231 to 240 of about 5,764,428 (380)

Isolation, identification and optimization of biomass production of native Spirulina species from South of the Caspian Sea. [PDF]

MethodsX
Shakoori M, Safari R, Makhlough A, Bagheri T.   +3 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

DNA barcoding for elasmobranch diversity assessment in Thailand: Its advantages and limitations. [PDF]

PLoS One
Khudamrongsawat J, Krajangdara T, Panithanarak T, Karuwancharoen R, Klangnurak W, Promnun P, Senanan W.   +6 more
europepmc   +1 more source

Conditional robustness analysis for fragility discovery and target identification in biochemical networks and in cancer systems biology [PDF]

, 2015
Fortunato Bianconi, Elisa Baldelli, Vienna Luovini, Emanuel F. Petricoin, Lucio Crinò, Paolo Valigi   +5 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Editorial for Special Issue "Linking Genomic Changes with Cancer in the NGS Era, 2nd Edition". [PDF]

Curr Issues Mol Biol
Azúa-Romeo J.
europepmc   +1 more source

Networks in Biology – From Identification, Analysis to Interpretation [PDF]

, 2009
Jesper Tegnér
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Data-driven identification of biological systems using multi-scale analysis. [PDF]

PLoS Comput Biol
Muhammed I, Manias DM, Goussis DA, Hatzikirou H.   +3 more
europepmc   +1 more source

The BCG strain: newer knowledge of its biology and identification.

, 1958
Armand Frappier, M Panisset
openalex   +1 more source