Results 241 to 250 of about 5,558,675 (362)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Is <i>Ornithoctona laticornis</i> (Diptera: Hippoboscidae) expanding its range from Africa into Europe? First confirmed record in Romania. [PDF]

Int J Parasitol Parasites Wildl
Oboňa J, Čisovská Bazsalovicsová E, Juhásová Ľ, Manko P, Mlynárová L, Pintilioaie AM, Topală LE, Králová-Hromadová I, Hromada M.   +8 more
europepmc   +1 more source

Alkaloid compound identification of Rhodomyrtus tomentosa stem as biology instructional material for senior high school X grade

, 2017
Retno Ningrum, Elly Purwanti, Sukarsono Sukarsono   +2 more
openalex   +2 more sources

AI-based identification of therapeutic agents targeting GPCRs: introducing ligand type classifiers and systems biology

, 2023
Jonas Goßen, Rui P. Ribeiro, Dirk Bier, Bernd Neumaier, Paolo Carloni, Alejandro Giorgetti, Giulia Rossetti   +6 more
openalex   +2 more sources

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

Nature Reviews Rheumatology, 2016
G. Kalliolias, L. Ivashkiv
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

LC-MS Orbitrap-based metabolomics using a novel hybrid zwitterionic hydrophilic interaction liquid chromatography and rigorous metabolite identification reveals doxorubicin-induced metabolic perturbations in breast cancer cells. [PDF]

RSC Adv
Abdelrazig S, McCabe Á, Yasin A, Chaudhary R, Ochsenkühn MA, Scicchitano D, Amin SA.   +6 more
europepmc   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Data on visitation records from wild bees and plants along a land use gradient in Germany and Belgium: laboratory work and protocol description for barcoding. [PDF]

Data Brief
Parreño MA, Werle S, Buydens L, Spitz J, Härtl F, Montoya J, Ruedenauer F, Arisoy B, Seiler R, Leroy C, Feng-Spitz Q, Nebauer CA, Ferrari A, Proessl N, Borchardt R, Peters B, Siebler S, Reese M, Schumacher N, Phung T, Schildt K, Ebensberger J, Seiler M, Reiter P, Beelaert S, Buydens M, Koirala S, Moreniere J, Tänzler R, Alaux C, Filipiak M, Meeus I, Piot N, Kuhlmann M, Requier F, Klein A, Brunet JL, Henry M, Keller A, Leonhardt SD.   +39 more
europepmc   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source