Results 41 to 50 of about 5,558,675 (362)

Circulating tumor cells: biology and clinical significance

Signal Transduction and Targeted Therapy, 2021
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against ...
Danfeng Lin, Lesang Shen, Meng Luo, Kun Zhang, Jinfan Li, Qi Yang, Fangfang Zhu, D-W Zhou, Shu Zheng, Yiding Chen, Jiaojiao Zhou   +10 more
semanticscholar   +1 more source

A question of biology [PDF]

Nature, 2004
Complete genome sequences have provided a plethora of potential drug targets. But the hard task of finding their weak spots is just beginning, as Caitlin Smith finds out.
openaire   +3 more sources

Genetics and molecular biology: identification of dyslipidemia genes [PDF]

Current Opinion in Lipidology, 2010
New approaches to determine which common genetic variants may be responsible for lipid disorders within the wider population particularly the association between clinical phenotype and single nucleotide polymorphisms (SNPs) or genetic loci in multiple genes. These systematic genome-wide association studies (GWAS) have identified several new loci.
Dino Rotondo, Jillian Davidson
openaire   +2 more sources

Biology, vulnerabilities and clinical applications of circulating tumour cells

Nature Reviews. Cancer, 2022
In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading to new fields of research and fostering the promise for paradigm ...
A. Ring, B. Nguyen-Sträuli, A. Wicki, N. Aceto   +3 more
semanticscholar   +1 more source

Xenopus: An ideal system for chemical genetics [PDF]

, 2012
Chemical genetics, or chemical biology, has become an increasingly powerful method for studying biological processes. The main objective of chemical genetics is the identification and use of small molecules that act directly on proteins, allowing rapid ...
Adams, Adams, Almogy, Banaszynski, Blackiston, Blackiston, Brändli, Cambridge, Carneiro, Chae, Chang, Chen, Clark, Dale, Das, Davidson, Deiters, Dodd, Dupre, Dush, Fini, Frank-Kamenetsky, Fukumoto, Garcia-Morales, Goda, Grammer, Hanvey, Hartley, Heasman, Horb, Huang, Kalin, Kolm, Lennox, Levin, Liu, Liu, Liu, Longo, Love, Lund, Meijer, Morckel, Nielsen, Nusslein-Volhard, Obika, Paddison, Page-McCaw, Peterson, Peterson, Pownall, Rankin, Reya, Richards, Rones, Schneider, Shestopalov, Stankunas, Tomlinson, Tomlinson, Tomlinson, Tomlinson, Tomlinson, Van Raay, Vandenberg, Verma, Wahlestedt, Walsh, Wheeler, Wheeler, White, Wignall, Woolf, Yang   +73 more
core   +1 more source

Identification of longevity genes with systems biology approaches

Advances and Applications in Bioinformatics and Chemistry, 2009
Identification of genes involved in the aging process is critical for understanding the mechanisms of age-dependent diseases such as cancer and diabetes. Measuring the mutant gene lifespan, each missing one gene, is traditionally employed to identify longevity genes.
John Bush, Fusheng Tang, Yuanyou Tan, Weijiu Liu   +3 more
openaire   +5 more sources

Oncogenic microRNAs characterization in clear cell renal cell carcinoma [PDF]

, 2015
A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of
BELLISSIMO, TERESA, CARBONE, Antonio, DELLA ROCCA, Carlo, DI CARLO, ANGELINA, FAZI, Francesco, PALLESCHI, GIOVANNI, PASTORE, ANTONIO LUIGI, PETROZZA, Vincenzo, PORTA, NATALE   +8 more
core   +2 more sources

Toxin–antitoxin systems [PDF]

Mobile Genetic Elements, 2013
Toxin-antitoxin (TA) systems are small genetic elements composed of a toxin gene and its cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are either proteins or non-coding RNAs. Based on the molecular nature of the antitoxin and its mode of interaction with the toxin the TA modules are currently grouped into five ...
Brigitte Poppenberger, Simon J. Unterholzner, Wilfried Rozhon   +2 more
openaire   +3 more sources

Unambiguous identification of fungi: where do we stand and how accurate and precise is fungal DNA barcoding?

IMA Fungus, 2020
True fungi (Fungi) and fungus-like organisms (e.g. Mycetozoa, Oomycota) constitute the second largest group of organisms based on global richness estimates, with around 3 million predicted species.
R. Lücking, M. C. Aime, B. Robbertse, A. Miller, H. Ariyawansa, T. Aoki, G. Cardinali, P. Crous, Irina S Druzhinina, D. Geiser, D. L. Hawksworth, K. Hyde, L. Irinyi, R. Jeewon, P. Johnston, P. Kirk, E. Malosso, T. May, W. Meyer, M. Öpik, V. Robert, M. Stadler, M. Thines, D. Vu, Andrey M. Yurkov, Ning Zhang, C. Schoch   +26 more
semanticscholar   +1 more source

Identification of Piecewise Linear Models of Complex Dynamical Systems

, 2011
The paper addresses the realization and identification problem or a subclass of piecewise-affine hybrid systems. The paper provides necessary and sufficient conditions for existence of a realization, a characterization of minimality, and an ...
Peeters, Ralf L. M., Petreczky, Mihály, Westra, Ronald L.   +2 more
core   +2 more sources