Results 111 to 120 of about 4,294,478 (314)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Influence of Parents Knowledge and Health Care Access to the Identification of Children with Hearing Impairment

Berkala Kedokteran, 2019
: Early identification and access to quality habilitative services designed for children with hearing loss is the key to developing language and communication skills commensurate with the children’s cognitive abilities.
Asti Widuri, Muhammad Pringgo Arifianto
doaj   +1 more source

Patient acceptability of, and attitudes towards, hepatitis B cure research - A scoping review and identification of knowledge gaps. [PDF]

J Virus Erad, 2023
Mohtashemi N, Dubé K, Thio C, Song S, Patel S, Sugarman J, Bhattacharya D.   +6 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

The spread of the omicron variant: Identification of knowledge gaps, virus diffusion modelling, and future research needs. [PDF]

Environ Res, 2023
Anand U, Pal T, Zanoletti A, Sundaramurthy S, Varjani S, Rajapaksha AU, Barceló D, Bontempi E.   +7 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Sex differences in aortic stenosis: Identification of knowledge gaps for sex-specific personalized medicine. [PDF]

Am Heart J Plus, 2022
Iribarren AC, AlBadri A, Wei J, Nelson MD, Li D, Makkar R, Merz CNB.   +6 more
europepmc   +1 more source

Joint Person Re-identification and Camera Network Topology Inference in Multiple Cameras

, 2017
Person re-identification is the task of recognizing or identifying a person across multiple views in multi-camera networks. Although there has been much progress in person re-identification, person re-identification in large-scale multi-camera networks ...
Cho, Yeong-Jun, Kim, Su-A, Lee, Kyuewang, Park, Jae-Han, Yoon, Kuk-Jin   +4 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Identification of research hypotheses and new knowledge from scientific literature

BMC Medical Informatics and Decision Making, 2018
Background Text mining (TM) methods have been used extensively to extract relations and events from the literature. In addition, TM techniques have been used to extract various types or dimensions of interpretative information, known as Meta-Knowledge ...
Matthew Shardlow, Riza Batista-Navarro, Paul Thompson, Raheel Nawaz, John McNaught, Sophia Ananiadou   +5 more
doaj   +1 more source