Results 141 to 150 of about 4,294,478 (314)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

How do young identify plants? Using the drawing method to explore early ethnobotanical knowledge in Madagascar

People and Nature
In small‐scale societies, people learn to identify plant species during childhood. Plant recognition is an important baseline knowledge, immediately useful to avoid intoxication risk due to wrong identification.
Vincent Porcher, Sandrine Gallois, Victoria Reyes‐García, Sitrakinaina Clara Raketabakoly, Santiago Alvarez‐Fernández, Stéphanie M. Carrière   +5 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Germanium in the environment: Current knowledge and identification of gaps

Soil & Environmental Health
Trace element germanium (Ge) plays a key role in some modern technologies including fibre optics, infrared optics, and semiconductors, but remains under-researched in environmental contexts. Naturally occurring in low concentrations, Ge behaves similarly
Montserrat Filella, Juan Carlos Rodríguez-Murillo   +1 more
doaj   +1 more source

Local Knowledge Spillovers, Innovation and Economic Performance in Developing Countries: A discussion of alternative specifications [PDF]

This paper examines the importance of local knowledge spillovers for the innovative and economic performance of firms in a developing country context. Theoretical and empirical studies in advanced economies underline the significance of local knowledge ...
Kesidou, Effie, Szirmai, Adam
core  

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Multilevel analysis of the effect of job characteristics on knowledge sharing mediating role of organizational identification.

Iranian Journal of Information Processing & Management, 2018
Today, the issue of knowledge acquisition and share it in the work field, especially in knowledge-based organizations, it has become more important. A library is a knowledge-oriented organization and the librarians are knowledge worker in the library. So
Faraj Allah Rahimi, Reza salehi
doaj  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The rôle of knowledge in system risk identification and assessment: The 2014 Ebola outbreak

Journal of the Operational Research Society, 2018
J. Powell, N. Mustafee, C. Brown
semanticscholar   +1 more source