Results 141 to 150 of about 623,880 (297)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Evidence Use and Identifier-Conditioned Prior Knowledge in Large Language Model Classification of Oncology Trials Assessed Through Progressive Content Removal and Counterfactual Testing: Comparative Analysis. [PDF]

JMIR AI
Windisch P, Koechli C, Dennstädt F, Aebersold DM, Zwahlen DR, Förster R, Schröder C.   +6 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The evolving role of immunotherapy in ovarian cancer. [PDF]

Cancer
Veneziani AC, Venegas L, Oza AM.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Protocol for histology-anchored macroscopic staging of gonadal maturity in exploited fishes. [PDF]

STAR Protoc
Santos R, Cruz M, Medeiros-Leal W, Rosa MD, Canha Â, Braga-Henriques A, Peixoto U.   +6 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Persistent Identifier für wissenschaftliche Einrichtungen

, 2018
In der vorliegenden Arbeit werden Probleme bei der eindeutigen Identifizierung wissenschaftlicher Einrichtungen aufgezeigt, Persistent Identifier als Lösung dieser Probleme vorgeschlagen und bereits bestehende Lösungsansätze in Form von ...
Rothfritz, Laura
core  

DAVID: a web server for functional annotation and functional enrichment analysis of gene lists (2025 update). [PDF]

Nucleic Acids Res
Sherman BT, Panzade G, Dotrang T, Hao M, Xu L, Li X, Baseler MW, Lane HC, Imamichi T, Chang W.   +9 more
europepmc   +1 more source