Results 161 to 170 of about 623,880 (297)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Identifying fundamental gaps in functional metagenomics: a step towards unlocking microbiome research potential. [PDF]
NAR Genom BioinformTiwari SK, Telatin A, Singh D.
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
This presentation discusses the different perspectives of researchers within the humanities and from a computer scientist and web archivist. The presentation will cover challenges and experiences from each perspective as well as future potentials in ...
Nyvang, Caroline, Zierau, Eld
core
Reframing ontology fact acquisition during large language model fine-tuning as a time-to-event process. [PDF]
Front Artif IntellHier DB, Obafemi-Ajayi T.
europepmc +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Recording of a presentation that discusses the different perspectives of researchers within the humanities and from a computer scientist and web archivist.
Nyvang, Caroline, Zierau, Eld
core
Validation of the DIVAS-Q (Day-to-Day Impact of Vulvovaginal Atrophic Symptoms Questionnaire): a Portuguese patient-reported outcome measure. [PDF]
J Patient Rep OutcomesAntunes A +5 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
CellExLink: End-to-end cell-type recognition and normalization in biomedical text. [PDF]
PLoS Comput BiolNabijiang A, Shahriyari L.
europepmc +1 more source