Results 131 to 140 of about 23,475,082 (277)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
On the Computational Cost of Cocks’ Identity Based Encryption [PDF]
, 2018 Identity Based Encryption is a public key cryptosystem where the user’s identity becomes the public key. The first Identity Based Encryption scheme was constructed in 2001 based on elliptic curves and with pairings.
Moo, Gabriel Ka Lin +2 more
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Improved identity-based online/offline encryption
, 2015 The notion of online/offline encryption was put forth by Guo, Mu and Chen (FC 2008), where they proposed an identity-based scheme called identity-based online/offline encryption (IBOOE).
Willy Susilo (19588021) +3 more
core +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Attribute-based encryption implies identity-based encryption
In this study, the author formally proves that designing attribute-based encryption schemes cannot be easier than designing identity-based encryption schemes.
Herranz Sotoca, Javier
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Unbounded and revocable hierarchical identity-based encryption with adaptive security, decryption key exposure resistant, and short public parameters. [PDF]
PLoS One, 2018 Xing Q, Wang B, Wang X, Tao J.
europepmc +1 more source