Results 61 to 70 of about 172,096 (252)
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Extreme overvalued beliefs and identities: revisiting the drivers of violent extremism
Frontiers in PsychologyRecent efforts to understand violent extremism have appealed to the concept of extreme overvalued beliefs as a way of explaining fixation and extremist commitments.
Kolbrun Kristinsdottir +5 more
doaj +1 more source
Independent and Interdependent? Agentic and Communal? Self-construals of People Fused with a Group
Anales de Psicologia, 2018 Four studies were conducted to examine how self and group identity fusion is related to self- construals, self-perception of agentic and communal traits, and the desire for self- and group verification.
Tomasz Besta
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Football, fan violence, and identity fusion [PDF]
International Review for the Sociology of Sport, 2017 Football violence has been a global problem for decades. A new way to approach the phenomenon comes from the theory of identity fusion, an extreme form of social bonding implicated in personally costly pro-group behaviours. Using British and Brazilian fan cultures to illustrate, this article discusses the ways in which identity fusion can help ...
openaire +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Frontiers in Social PsychologyObjectiveStudies on radicalization require a nuanced understanding of the narratives that legitimize violent actions, as well as the complex processes underlying radicalization, in order to formulate effective and targeted counter-radicalization ...
Norberta Fauko Firdiani +4 more
doaj +1 more source