Results 81 to 90 of about 518,478 (263)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Unstable Adams operations on p-local compact groups

, 2011
A p-local compact group is an algebraic object modelled on the p-local homotopy theory of classifying spaces of compact Lie groups and p-compact groups. In the study of these objects unstable Adams operations, are of fundamental importance. In this paper
Assaf Libman, Beyl, Borel, Bousfield, Brown, Fabien Junod, Ran Levi, Robert, Weibel   +8 more
core   +1 more source

Identity fusion: a systematic review

, 2020
Abstract The objective of the present investigation was to conduct a systematic review of empirical studies that have reported the use of identity fusion theory. The review followed guidelines and recommendations of the PRISMA statement. The following databases were used Web of Science, Scopus, ProQuest, ScienceDirect, Willey Online Library, EBSCO and ...
Henríquez, Diego, Urzúa, Alfonso, López-López, Wilson   +2 more
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

What keeps them invested? Social identity and group formation in blockchain

Frontiers in Blockchain
Cryptocurrency technologies have spawned a vast network of millions of users. One notable aspect of crypto spaces is the emergence of vibrant communities that form around specific projects, with supporters gathering on interactive online platforms and ...
Annika Aebli, Fabienne Silberstein-Bamford, Fabienne Silberstein-Bamford, Joshua S. Bamford, Joshua S. Bamford, Joshua S. Bamford   +5 more
doaj   +1 more source

Cognitive Linguistic Identity Fusion Score (CLIFS): A Scalable Cognition‐Informed Approach to Quantifying Identity Fusion from Text

Proceedings of the 2025 Conference on Empirical Methods in Natural Language Processing
Quantifying identity fusion -- the psychological merging of self with another entity or abstract target (e.g., a religious group, political party, ideology, value, brand, belief, etc.) -- is vital for understanding a wide range of group-based human behaviors.
Wright, Devin R., An, Jisun, Ahn, Yong-Yeol   +2 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Reduced, tame and exotic fusion systems

, 2010
We define here two new classes of saturated fusion systems, reduced fusion systems and tame fusion systems. These are motivated by our attempts to better understand and search for exotic fusion systems: fusion systems which are not the fusion systems of ...
Andersen, Kasper K. S., Oliver, Bob, Ventura, Joana   +2 more
core   +3 more sources