Results 91 to 100 of about 50,635 (295)

Inflammatory disorders in IDH‐mutated myeloid neoplasms: Characteristics and response to IDH inhibitors

HemaSphere
Myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) are heterogeneous clonal disorders that may be associated with immune-mediated inflammatory disorders (IMIDs), reported in up to 25% of patients.1-4 The contribution of clonal hematopoiesis to systemic inflammation is increasingly recognized, exemplified by the recently described
Stammler, Romain, Chen, Peter, Debeaupuis, Orianne, Zhao, Lin‐pierre, Ruyer‐thompson, Mirabelle, Zakine, Eve, Rossignol, Julien, Goldwirt, Lauriane, Comont, Thibault, Heiblig, Maël, Adès, Lionel, Sebert, Marie, Allain, Jean‐sébastien, Campagne, Julien, Couturier, Marie‐anne, Cumin, Marina, Dalmas, Marie‐caroline, Denis, Guillaume, Devloo, Cécile, de Voeght, Adrien, Drevon, Louis, Duffau, Pierre, Georgin‐lavialle, Sophie, Gobert, Delphine, Kosmider, Olivier, Rieux‐laucat, Frédéric, Abisror, Noémie, Lazaro, Estibaliz, Lopez, Jean‐guillaume, Maria, Alexandre, Mauhin, Wladimir, Merindol, Julie, Merlot, Claire, Mirault, Tristan, Pascal, Laurent, Perrin, François, Raffoux, Emmanuel, Rahme, Ramy, Roos‐weil, Damien, Terrier, Benjamin, Thoreau, Benjamin, Fain, Olivier, Fenaux, Pierre, Hirsch, Pierre, Jachiet, Vincent, Hadjadj, Jérôme, Mékinian, Arsène   +46 more
openaire   +3 more sources

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

La palabra desquiciada. Sobre Periférica Boulevard. Ópera rock-ocó

Revista de Estudos Literários da UEMS - REVELL, 2018
Analizaré en este artículo la novela Periférica Blvd. Ópera rock-ocó (2004) de Adolfo Cárdenas y su apuesta por volver a la lengua literaria boliviana más decidora, desde una pregunta por la práctica alterada de la lengua y la relación de la escritura ...
Mariana Ines Lardone
doaj  

DNA methylation microarray analysis of adult gliomas: A pilot study at Groote Schuur Hospital

South African Journal of Oncology
Background: Accurate glioma diagnosis requires a combination of histology, radiology and identification of key genetic mutations. Currently, multiple tests are required to identify these mutations.
Brendon Price
doaj   +1 more source

Associations between body composition and intradialytic hypotension (IDH), and between IDH and prognosis, in hemodialysis patients

Background Previous studies describing relationships among body compositions, intradialytic hypotension (IDH), and mortality yielded inconsistent results.
Sonoo Mizuiri, Toshiki Doi, Koji Usui, Kenichi Morii, Kenichiro Shigemoto, Takao Masaki, Yoshiko Nishizawa, Kazuomi Yamashita, Aiko Okubo, Yukari Suga   +9 more
core   +1 more source

IDH Mutations in Chondrosarcoma: Case Closed or Not?

, 2023
Chondrosarcomas are malignant cartilage-producing tumours that frequently harbour isocitrate dehydrogenase 1 and -2 (IDH) gene mutations. Several studies have confirmed that these mutations are key players in the early stages of cartilage tumour ...
Sanne Venneker, Judith V. M. G. Bovée
core   +1 more source

Conceptualizing Corporate Political Activity for Sustainability Governance—The CPA Cube

Business Strategy and the Environment, EarlyView.
ABSTRACT Sustainability transformations in the economy, and related public policy decisions, are highly contested, attracting business involvement. To better understand how business influence on government impacts the success or failure of sustainability governance efforts, this paper extends the literature on corporate political activity (CPA) by ...
Burkard Eberlein, Janina Grabs
wiley   +1 more source

Intensive Induction in AML in the Era of Venetoclax: A Standing Count for “7 + 3”?

American Journal of Hematology, EarlyView.
Sudhir Tauro, Ayalew Tefferi
wiley   +1 more source