Results 1 to 10 of about 35,587 (246)

Wild-Type IDH1 and Mutant IDH1 Opposingly Regulate Podoplanin Expression in Glioma

Translational Oncology, 2020
Isocitrate dehydrogenase (IDH) mutations occur frequently in lower-grade gliomas, which result in genome-wide epigenetic alterations. The wild-type IDH1 is reported to participate in lipid biosynthesis and amino acid metabolism, but its role in ...
Chao Sun, Liming Xiao, Yuanlin Zhao, Jiankuan Shi, Yuan Yuan, Yu Gu, Feng Zhang, Xing Gao, Ying Yang, Risheng Yang, Junhui Qin, Jin Zhang, Chao Wang, Yingmei Wang, Zhe Wang, Peizhen Hu, Ting Chang, Liang Wang, Gang Wang, Huangtao Chen, Zhuyi Li, Jing Ye   +21 more
doaj   +3 more sources

Crotonylation of IDH1 alleviates MASLD progression by enhancing the TCA cycle [PDF]

Nature Communications
Metabolic dysfunction–associated steatotic liver disease (MASLD), potentially ameliorated by bariatric-metabolic surgery, remains a global health concern in the absence of approved drugs.
Shanshan Liu, Yu Ji, Luyang Wei, Yiqiao Zhang, Linghang Zeng, Yiyang Min, Danyang Yin, Kun Liu, Chengjian Guan, Shumeng Liu, Huajing Yu, Zhongtao Zhang   +11 more
doaj   +2 more sources

Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma [PDF]

Genome Biology
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma.
William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur-Lombardelli, PEACE consortium, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M. Flanagan, Peter Van Loo   +15 more
doaj   +2 more sources

The expression and significance of IDH1 and p53 in osteosarcoma [PDF]

Journal of Experimental & Clinical Cancer Research, 2010
Background To detect the expression of isocitrate dehydrogenase 1 (IDH1) and transformation-related protein 53 (p53) in osteosarcoma and analyze the correlation between them and the clinico-pathological features.
Zhou Min, Wu Gang, Fu Tao, Qi Bai-Wen, Yu Ai-Xi, Hu Xiang, Luo Jun, Xu Jun-Hua   +7 more
doaj   +3 more sources

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

eLife
Isocitrate dehydrogenase 1 (IDH1) is the key enzyme that can modulate cellular metabolism, epigenetic modification, and redox homeostasis. Gain-of-function mutations and decreased expression of IDH1 have been demonstrated to be associated with ...
Mengjia Li, Hengchao Zhang, Xiuyun Wu, Mengqi Yu, Qianqian Yang, Lei Sun, Wei Li, Zhongxing Jiang, Fumin Xue, Ting Wang, Xiuli An, Lixiang Chen   +11 more
doaj   +2 more sources

Ivosidenib for IDH1-Mutant Intrahepatic Cholangiocarcinoma: Insights From a Multicenter Real-World Study. [PDF]

Liver Int
Niger M, Rimini M, Castet F, Melzer A, Rizzato MD, Pressiani T, Lavacchi D, Aprile G, Angela T, Saladino T, Silvia N, Cito P, Pastorino A, Terán-Brage E, Sciortino C, Camera S, Pircher C, Persano M, Mazzaferro V, Foti S, Vega KS, Ettrich TJ, Antonuzzo L, Rimassa L, Lonardi S, Perkhofer L, Macarulla T, Pietrantonio F, Casadei-Gardini A.   +28 more
europepmc   +3 more sources

Characterization of the human IDH1 gene promoter

AIMS Molecular Science, 2023
In cancer, the production of ATP depends mainly on glycolysis, usually accompanied by the dysfunction of the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS).
Yutaka Takihara, Ryuji Otani , Takuro Ishii, Shunsuke Takaoka, Yuki Nakano , Kaori Inoue, Steven Larsen, Yoko Ogino , Masashi Asai , Sei-ichi Tanuma , Fumiaki Uchiumi   +10 more
doaj   +1 more source

Gene of the month: IDH1 [PDF]

Journal of Clinical Pathology, 2020
Isocitrate dehydrogenase 1 (IDH1) encodes a protein which catalyses the oxidative decarboxylation of isocitrate to α-ketoglutarate. Mutant IDH1 favours the production of 2-hydroxyglutarate, an oncometabolite with multiple downstream effects which promote tumourigenesis. IDH1 mutations have been described in a number of neoplasms most
Cassandra Bruce-Brand, Dhirendra Govender   +1 more
openaire   +2 more sources

Combination treatment of an IDH1 inhibitor with chemotherapy in IDH1 mutant acute myeloid leukemia [PDF]

Annals of Hematology, 2020
Patients with newly diagnosed chronic phase chronic myeloid leukemia (CP CML) can be effectively treated with tyrosine kinase inhibitors (TKIs) and achieve a lifespan similar to the general population. The success of TKIs, however, requires long-term and sometimes lifelong treatment; thus, patient-assessed health-related quality of life (HRQoL) has ...
Gupta, Charu, Kaulfuss, Stefan, Görlich, Kerstin, Othman, Basem, Chaturvedi, Anuhar, Heuser, Michael   +5 more
openaire   +3 more sources

Correlation of IDH1, p53 and Ki-67 immunoexpression levels with morphological, clinical prognostic parameters and preoperative/postoperative radiological findings and response to treatment in high-grade glial tumor case

Medicine Science, 2023
In this study, we aimed to investigate the prognostic factors affecting survival in adult patients with high-grade glial tumors. The retrospective study included 79 consecutive patients who were referred to our clinic for adjuvant radiotherapy ...
Murtaza Parvizi, Ulkun Unlu Unsal, Olcay Ak Nalbant, Derya Demir, Murat Akyol, Aydin Isisag   +5 more
doaj   +1 more source