Results 1 to 10 of about 58,205 (308)

Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma [PDF]

Genome Biology
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma.
William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur-Lombardelli, PEACE consortium, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M. Flanagan, Peter Van Loo   +15 more
doaj   +2 more sources

Crotonylation of IDH1 alleviates MASLD progression by enhancing the TCA cycle [PDF]

Nature Communications
Metabolic dysfunction–associated steatotic liver disease (MASLD), potentially ameliorated by bariatric-metabolic surgery, remains a global health concern in the absence of approved drugs.
Shanshan Liu, Yu Ji, Luyang Wei, Yiqiao Zhang, Linghang Zeng, Yiyang Min, Danyang Yin, Kun Liu, Chengjian Guan, Shumeng Liu, Huajing Yu, Zhongtao Zhang   +11 more
doaj   +2 more sources

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

eLife
Isocitrate dehydrogenase 1 (IDH1) is the key enzyme that can modulate cellular metabolism, epigenetic modification, and redox homeostasis. Gain-of-function mutations and decreased expression of IDH1 have been demonstrated to be associated with ...
Mengjia Li, Hengchao Zhang, Xiuyun Wu, Mengqi Yu, Qianqian Yang, Lei Sun, Wei Li, Zhongxing Jiang, Fumin Xue, Ting Wang, Xiuli An, Lixiang Chen   +11 more
doaj   +2 more sources

Characterization of the human IDH1 gene promoter

AIMS Molecular Science, 2023
In cancer, the production of ATP depends mainly on glycolysis, usually accompanied by the dysfunction of the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS).
Yutaka Takihara, Ryuji Otani , Takuro Ishii, Shunsuke Takaoka, Yuki Nakano , Kaori Inoue, Steven Larsen, Yoko Ogino , Masashi Asai , Sei-ichi Tanuma , Fumiaki Uchiumi   +10 more
doaj   +1 more source

Correlation of IDH1, p53 and Ki-67 immunoexpression levels with morphological, clinical prognostic parameters and preoperative/postoperative radiological findings and response to treatment in high-grade glial tumor case

Medicine Science, 2023
In this study, we aimed to investigate the prognostic factors affecting survival in adult patients with high-grade glial tumors. The retrospective study included 79 consecutive patients who were referred to our clinic for adjuvant radiotherapy ...
Murtaza Parvizi, Ulkun Unlu Unsal, Olcay Ak Nalbant, Derya Demir, Murat Akyol, Aydin Isisag   +5 more
doaj   +1 more source

Identification of Mutations in IDH1/2, DNMT3A, ASXL1 Genes of Genome Epigenetic Regulation and Their Co-Occurrence with FLT3, NPM1, RUNX1 Mutations in Acute Myeloid Leukemia

Клиническая онкогематология, 2021
Aim. To identify mutations in IDH1/IDH2, DNMT3A, and ASXL1 genes responsible for genome epigenetic regulation and their co-occurrence with FLT3, NPM1, and RUNX1 mutations in newly diagnosed adult acute myeloid leukemias (AML). Materials & Methods. The
Ekaterina Vasilevna Belotserkovskaya, E. K. Zaikova, A. V. Petukhov, O. N. Demidov, K. A. Levchuk, I. G. Budaeva, D. V. Zaitsev, Yu. D. Rogovaya, A. A. Shatilova, K. V. Bogdanov, Yu. V. Mirolyubova, T. S. Nikulina, A. Yu. Zaritskey, L. L. Girshova   +13 more
doaj   +1 more source

IDH1 mutation promotes lung cancer cell proliferation through methylation of Fibulin-5 [PDF]

Open Biology, 2018
Mutation in isocitrate dehydrogenase (IDH) leads to an aberrant function of the enzyme, leading to the production of hydroxyglutarate, as well as changes in cellular metabolism, DNA methylation and histone modification.
Bingdi Yan, Yanbing Hu, Tiangang Ma, Yanjun Wang   +3 more
doaj   +1 more source

Isocitrate dehydrogenase 1 mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis

Open Medicine, 2022
The present study intends to clarify the hypothesis that isocitrate dehydrogenase 1 (IDH1) mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis through the in vitro and in vivo experiments.
Su Li, Huang Yi, Zheng Lei, Zhu Zhifa, Wu Yue, Li Ping   +5 more
doaj   +1 more source

Retrospective and Randomized Analysis of Influence and Correlation of Clinical and Molecular Prognostic Factors in a Mono-Operative Series of 122 Patients with Glioblastoma Treated with STR or GTR

Brain Sciences, 2020
Glioblastoma is a solid, infiltrating, and the most frequent highly malignant primary brain tumor. Our aim was to find the correlation between sex, age, preoperative Karnofsky performance status (KPS), presenting with seizures, and extent of resection ...
Maurizio Salvati, Placido Bruzzaniti, Michela Relucenti, Mariagrazia Nizzola, Pietro Familiari, Marco Giugliano, Anthony Kevin Scafa, Santi Galletta, Xiaobo Li, Rui Chen, Claudio Barbaranelli, Alessandro Frati, Antonio Santoro   +12 more
doaj   +1 more source

Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics

Biomolecules, 2021
Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP+-dependent oxidation of isocitrate to α-ketoglutarate (αKG). IDH1 mutations, primarily R132H, drive > 80% of low-grade gliomas and secondary glioblastomas and facilitate the NADPH-dependent ...
Joi Weeks, Alexandra I. Strom, Vinnie Widjaja, Sati Alexander, Dahra K. Pucher, Christal D. Sohl   +5 more
doaj   +1 more source