Results 91 to 100 of about 58,205 (308)
Oncometabolites: tailoring our genes [PDF]
, 2015 Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core +1 more source
Haematologica, 2020 Mutant IDH1 (mIDH1) inhibitors have shown single-agent activity in relapsed/refractory AML, though most patients eventually relapse. We evaluated the efficacy and molecular mechanism of the combination treatment with azacitidine, which is currently the standard of care in older AML patients, and mIDH1 inhibitor BAY1436032. Both compounds were evaluated
Anuhar Chaturvedi, +17 more
openaire +5 more sources
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α [PDF]
Science, 2009 Heterozygous mutations in the gene encoding isocitrate dehydrogenase-1 ( IDH1 ) occur in certain human brain tumors, but their mechanistic role in tumor development is unknown. We have shown that tumor-derived IDH1 mutations impair the enzyme's affinity
Shimin, Zhao +13 more
openaire +2 more sources
Conditional survival in glioblastoma: The evolution of prognostic factors over time
International Journal of Cancer, EarlyView.What's New? Neurooncologists rely on glioblastoma risk stratification systems for incorporating known disease‐ and patient‐specific factors at diagnosis. Although useful for general comparison and disease monitoring, these estimates are less informative for patients who survive beyond various time intervals post‐diagnosis.
Timothy Mueller +19 more
wiley +1 more source
Persistent IDH1/2 mutations in remission can predict relapse in patients with acute myeloid leukemia
Haematologica, 2019 Persistence of IDH1 or IDH2 mutations in remission bone marrow specimens of patients with acute myeloid leukemia has been observed, but the clinical impact of these mutations is not well known.
Chi Young Ok +17 more
doaj +1 more source
IDH1/2 Mutants Inhibit TET-Promoted Oxidation of RNA 5mC to 5hmC. [PDF]
PLoS ONE, 2016 TETs (TET1/2/3) play critical roles in multi cellular processes through DNA demethylation driven by oxidation of DNA 5mdC to 5hmdC. Interestingly, recent studies indicated that TETs also oxidate RNA 5mC to 5hmC.
Qiang Xu +6 more
doaj +1 more source
Cancer metabolism at a glance [PDF]
, 2016 A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and ...
Gottlieb, Eyal +5 more
core +2 more sources
Interdisciplinary Medicine, EarlyView.We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li +10 more
wiley +1 more source
cyTRON and cyTRON/JS: two Cytoscape-based applications for the inference of cancer evolution models
, 2017 The increasing availability of sequencing data of cancer samples is fueling the development of algorithmic strategies to investigate tumor heterogeneity and infer reliable models of cancer evolution.
D Ramazzotti +10 more
core +1 more source
IDH1: function follows form [PDF]
Science-Business eXchange, 2009 Researchers at Agios Pharmaceuticals have shown that a common cancer-associated mutation causes the enzyme IDH1 to acquire a new catalytic activity while stripping it of its native one. The biotech is exploring the therapeutic potential of its discovery in gliomas and secondary glioblastomas.
openaire +1 more source