Results 101 to 110 of about 35,587 (246)
Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression
Cell Death and DiseaseIsochlorate dehydrogenase 1 (IDH1) is an important metabolic enzyme for the production of α-ketoglutarate (α-KG), which has antitumor effects and is considered to have potential antitumor effects.
Zhao Cui +7 more
doaj +1 more source
Novel IDH1-Targeted Glioma Therapies
CNS Drugs, 2019 Mutations in the isocitrate dehydrogenase (IDH) 1 gene are commonly found in human glioma, with the majority of low-grade gliomas harboring a recurrent point mutation (IDH1 R132H). Mutant IDH reveals an altered enzymatic activity leading to the synthesis of 2-hydroxyglutarate, which has been implicated in epigenetic mechanisms of oncogenesis ...
Georg, Karpel-Massler +3 more
openaire +3 more sources
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Molecular and functional characterization of SMOC1 in IDH1 wild type and IDH1 mutant gliomas
, 2016 Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS)
Weber, MM +3 more
openaire +2 more sources
Epigenetic reprogramming in multiple myeloma—Challenges and opportunities
International Journal of Cancer, Volume 158, Issue 2, Page 423-432, 15 January 2026.Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar +2 more
wiley +1 more source
DNA methyltransferase inhibitors in hematological malignancies and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger +3 more
wiley +1 more source
Magnetic Resonance Spectroscopy of Cystathionine and 2‐Hydroxyglutarate in Brain Tumors
NMR in Biomedicine, Volume 39, Issue 1, January 2026.Cystathionine and 2‐hydroxyglutarate were evaluated in 38 glioma patients with TE 97ms PRESS at 3T. Cystathionine level was significantly higher in IDH‐mutant 1p/19q‐codeleted gliomas than in IDH‐mutant non‐codeleted gliomas (p = 0.002). The sensitivity and specificity of the cystathionine measures with respect to 1p/19q status were 0.8 and 0.79, while
Changho Choi +17 more
wiley +1 more source
Integration of omics data in the diagnosis and therapy of glioblastoma
Brain Pathology, Volume 36, Issue 1, January 2026.Integration of omics data in the diagnosis and therapy of glioblastoma. Abstract Since the 2016 update of the WHO Classification of Tumors of the Central Nervous System, omics data have been officially integrated into the diagnostic process for glioblastoma, the most prevalent and aggressive primary malignant brain tumor in adults.
Constantin Möller +3 more
wiley +1 more source
MUTANT IDH1 SUPPRESSES APOPTOSIS REGULATOR PAR-4 IN GLIOMAS [PDF]
, 2014 Craig Horbinski +3 more
openalex +1 more source