Results 101 to 110 of about 34,512 (245)

cIMPACT‐NOW update 11: Proposal on adaptation of diagnostic criteria for IDH‐ and H3‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors

Brain Pathology, EarlyView.
Abstract The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health Organization (WHO) classification.
Pieter Wesseling, David Capper, Guido Reifenberger, Chitra Sarkar, Cynthia Hawkins, Arie Perry, Bette Kleinschmidt‐DeMasters, Takashi Komori, Werner Paulus, Vani Santosh, Martin van den Bent, Michael Weller, Stefan M. Pfister, Uri Tabori, Dominique Figarella‐Branger, Brent A. Orr, David N. Louis   +16 more
wiley   +1 more source

Metabolic reprogramming in mutant IDH1 glioma cells.

PLoS ONE, 2015
BackgroundMutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70% of low-grade gliomas and secondary glioblastomas. IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while mutant IDH1 ...
Jose L Izquierdo-Garcia, Pavithra Viswanath, Pia Eriksson, Myriam M Chaumeil, Russell O Pieper, Joanna J Phillips, Sabrina M Ronen   +6 more
doaj   +1 more source

Machine Learning‐Based Predictive Modeling Maximizes the Efficacy of mTOR/p53 Co‐Targeting Therapy Against AML

Cancer Science, EarlyView.
Although mTOR inhibitors show limited clinical efficacy against AML, this study demonstrates that combining mTOR inhibition with TP53 activation enhances anti‐leukemic effects. We also developed a gene scoring system (Rapa‐11) predicting rapamycin sensitivity and showed that monocytic AMLs with wild‐type TP53 and low Rapa‐11 scores are highly ...
Jingmei Li, Emi Sugimoto, Keita Yamamoto, Yutong Dai, Wenyu Zhang, Yu‐Hsuan Chang, Jakushin Nakahara, Tomohiro Yabushita, Toshio Kitamura, Sung‐Joon Park, Kenta Nakai, Susumu Goyama   +11 more
wiley   +1 more source

Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression

Cell Death and Disease
Isochlorate dehydrogenase 1 (IDH1) is an important metabolic enzyme for the production of α-ketoglutarate (α-KG), which has antitumor effects and is considered to have potential antitumor effects.
Zhao Cui, Caifeng Li, Wei Liu, Mo Sun, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen   +7 more
doaj   +1 more source

Characterization of R132H Mutation‐specific IDH1 Antibody Binding in Brain Tumors [PDF]

, 2009
David Capper, Susanne Weißert, Jörg Balß, Antje Habel, Jochen Meyer, Diana Jäger, Ulrike Ackermann, Claudia Tessmer, Andrey Korshunov, Hanswalter Zentgraf, Christian Hartmann, Andreas von Deimling   +11 more
openalex   +1 more source

Tumor‐related epilepsy in glioma: A multidisciplinary overview

Epilepsia, EarlyView.
Abstract Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor‐related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an
Roberto Michelucci, Giada Pauletto, Antonio Silvani, Elena Pasini, Tamara Ius, Matteo Martinoni, Carlo Alberto Castioni, Andrea Salmaggi, Sofia Asioli, Marta Maschio, Giuseppe Minniti, Enrico Franceschi, Flavio Villani, Roberta Rudà, Eleonora Aronica, the Italian Multidisciplinary Group for Tumor Epilepsy, Paolo Vitali, Damiano Balestrini, Elisa D’Angelo, Lorenzo Bello, Marco Rossi, Marta Padovan, Anna Teresa Giallonardo, Carlo di Bonaventura, Francesco Toni, Angela La Neve, Simona Rizzato, Matteo Pugnaghi, Marco Vindigni, Carmelo Sturiale   +29 more
wiley   +1 more source

GFAP, Ki67 and IDH1: perhaps the golden triad of glioma immunohistochemistry [PDF]

, 2009
Werner Paulus
openalex   +1 more source

Early seizure freedom with [18F]fluorodopa positron emission tomography response after isocitrate dehydrogenase inhibition with vorasidenib: First case report

Epilepsia, EarlyView.
Abstract Vorasidenib, a dual isocitrate dehydrogenase 1/2 (IDH1/2) inhibitor, showed superior efficacy in prolonging progression‐free survival and time to next intervention in IDH‐mutant grade 2 gliomas. This case is part of an ongoing institutional study exploring the impact of vorasidenib on seizure control and the potential of [18F]fluorodopa (F ...
Roberta Rudà, Francesco Bruno, Alessia Pellerino, Edoardo Pronello, Michela Zotta, Silvia Morbelli   +5 more
wiley   +1 more source

FGFR2 Fusions or Rearrangements in Young Intrahepatic and Perihilar Cholangiocarcinoma Patients: Key Genetic Insights From a Pan‐Asian Study

Hepatology Research, EarlyView.
FGFR2 Alterations in Young Adults with cholangiocarcinoma was common. Intrahepatic cholangiocarcinoma (ICC) is a rare liver cancer, typically seen in older adults. This study focused on younger patients across Asia, examining changes in the FGFR2 gene that may drive cancer growth.
Yuta Maruki, Yasushi Yatabe, Chiharu Mizoguchi, Kathleen Yasmin de Almeida, Aumkhae Sookprasert, Charuwan Akewanlop, Ming‐Huang Chen, Ekaphop Sirachainan, Dao Van Tu, Rozita Abdul Malik, Chaiyut Charoentum, Hwoei Fen Soo Hoo, Suhana Yusak, Tsung‐Hao Liu, Rangasamy Ramachandran, Patrapim Sunpaweravong, Pei Jye Voon, Najihah Abu Bakar, Junki Mizusawa, Hitomi Sumiyoshi Okuma, Kenichi Nakamura, Chigusa Morizane, Takuji Okusaka   +22 more
wiley   +1 more source

IDH1 Gene Mutations: A New Paradigm in Glioma Prognosis and Therapy? [PDF]

, 2010
Marianne Labussière, Marc Sanson, Ahmed Idbaïh, Jean‐Yves Delattre   +3 more
openalex   +1 more source