Results 111 to 120 of about 35,587 (246)

Data from Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas

, 2023
Genglin Jin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojević, David M. Gooden, B. Ahmed Rasheed, Rui Yang, Giselle Y. López, Yiping He, Roger E. McLendon, Darell D. Bigner, Hai Yan   +11 more
openalex   +1 more source

cIMPACT‐NOW update 11: Proposal on adaptation of diagnostic criteria for IDH‐ and H3‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors

Brain Pathology, Volume 36, Issue 1, January 2026.
Abstract The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health Organization (WHO) classification.
Pieter Wesseling, David Capper, Guido Reifenberger, Chitra Sarkar, Cynthia Hawkins, Arie Perry, Bette Kleinschmidt‐DeMasters, Takashi Komori, Werner Paulus, Vani Santosh, Martin van den Bent, Michael Weller, Stefan M. Pfister, Uri Tabori, Dominique Figarella‐Branger, Brent A. Orr, David N. Louis   +16 more
wiley   +1 more source

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Disruption of Mitochondrial Dynamics and Integrity Drives Divergent Metabolic Flexibility and Resilience in Podocytes

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
We investigated two models of mitochondrial dysfunction in podocytes, using two cell culture models: podocytes isolated from mice with Oma1 deletion (Oma1del) and mouse podocytes modified with an inducible knockdown of PHB2 (Phb2kd). OMA1 deficiency induced a glycolytic shift, enhanced glutamine anaplerosis, and sustained energy homeostasis after ...
Cem Özel, Katrin M. Reitmeier, Emilia Kieckhöfer, Khawla Abualia, Duc Nguyen‐Minh, Mahsa Matin, Henning Hagmann, Richard J. M. Coward, Sebastian Brähler, Philipp Antczak, Bernhard Schermer, Thomas Benzing, Patrick Giavalisco, Paul T. Brinkkoetter   +13 more
wiley   +1 more source

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu   +5 more
wiley   +1 more source

Consequences of Acute Presentations of Functional Neurological Disorders in Neuro‐Oncology Patients: Case Series and Systematic Review

Brain and Behavior, Volume 15, Issue 12, December 2025.
Functional neurological disorders (FNDs) can present acutely at any stage of a brain tumor illness and may result in inappropriate investigations and treatment. Improved awareness of this issue will facilitate earlier diagnosis of FND, encourage development of multidisciplinary pathways to treat FND, and prevent delays to tumor treatment.
Stuart C. Innes, Dorothy K. Joe, Katia Cikurel, José P. Lavrador, Francesco Vergani, Ranj Bhangoo, Keyoumars Ashkan, Gerald T. Finnerty   +7 more
wiley   +1 more source

EXTH-80. IMPAIRED PARP1 DNA REPAIR DEFINES CHEMO-SENSITIVITY IN IDH1-MUTATED CELL [PDF]

, 2018
Yanxin Lu, Yang Liu, Mark R. Gilbert, Jing Wu, Chunzhang Yang   +4 more
openalex   +1 more source

Comprehensive Molecular Screening by Next Generation Sequencing of Gastrointestinal Stromal Tumors (GISTs): In Silico Analysis and Classification of Rare KIT Exon 11 Mutations

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Introduction Gastrointestinal stromal tumors (GISTs) originate from mesenchymal precursor cells of the gastrointestinal wall and account for approximately 3% of all gastrointestinal malignancies. In adults, these tumors most commonly harbor mutually exclusive activating mutations in KIT, PDGFRA, BRAF, or SDH‐family genes.
Maria Grazia Rodriquenz, Barbara Pasculli, Michelina Rendina, Francesco Petrizzelli, Tommaso Mazza, Antonio Petracca, Bartolomeo Augello, Michelina Coco, Teresa Balsamo, Anna Troiano, Magda Zanelli, Evaristo Maiello, Paolo Graziano, Paola Parente, Paola Parrella   +14 more
wiley   +1 more source

The Landscape of Bispecific Antibodies in Solid Tumor Oncology: Trends, Challenges, and Opportunities

Cancer Medicine, Volume 14, Issue 24, December 2025.
ABSTRACT Background Bispecific Antibodies (BsAbs) represent a novel class of immunoglobulins that can target and bind to two distinct antigens simultaneously. The global BsAbs market, valued at approximately USD 8.65 billion in 2023, reflects tremendous promise and substantial growth.
Rafik ElBeblawy, Chinmay Jani, Judith Pérez‐Granado, Mark Gramling, Aakash Desai   +4 more
wiley   +1 more source

TMEM106A as a Macrophage‐Associated Biomarker of Prognosis in IDH‐Wildtype Glioma: Integrative Multi‐Omics and Spatial Analyses

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Introduction Gliomas remain aggressive despite current therapies, highlighting the urgent need for new biomarkers and targets. Transmembrane protein 106A (TMEM106A), implicated as a tumor suppressor in various cancers, has an unclear role in gliomas. We hypothesized that TMEM106A expression associates with tumor aggressiveness and may serve as
Wen‐Shin Song, Pei‐Chi Chang, Dueng‐Yuan Hueng, Yao‐Feng Li   +3 more
wiley   +1 more source