Results 111 to 120 of about 63,359 (335)

Blood plasma lipid profile in glial tumors

Успехи молекулярной онкологии
Introduction. In glial tumors, lipid metabolism becomes abnormal. Analysis of lipid metabolism components can be an important characteristic of molecular and genetic profile of gliomas.Aim. To determine the correlation between plasma lipidome profile and
L. M. Obukhova, E. V. Balavina, T. A. Veselova, I. A. Medyanik, A. S. Grishin, V. F. Lazukin, M. M. Kontorshchikov   +6 more
doaj   +1 more source

5-hydroxymethylcytosine profiling as an indicator of cellular state [PDF]

, 2013
A Laird is supported by the Medical Research Council Scottish Clinical Pharmacology and Pathology Programme, The Royal College of Surgeons of Edinburgh Robertson’s Trust and The Melville Trust for the Care and Cure of Cancer.
Harrison, David J., Laird, Alexander, Meehan, Richard R., Thomson, John P.   +3 more
core   +1 more source

Molecular and functional characterization of SMOC1 in IDH1 wild type and IDH1 mutant gliomas

, 2016
Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS)
Weber, MM, Kaisers, W, Reifenberger, G, Knobbe-Thomsen, CB   +3 more
openaire   +2 more sources

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Prognostic significance of HIF1-α immunohistochemical expression in gliomas and it's relation to IDH1 mutation status

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Gliomas are the commonest primary adults’ brain tumors. Hypoxia performs an essential role in gliomas’ initiation as well as progression through hypoxia inducible factor (HIF-1α) activation, which could serve as a promising target in treatment
Eman Ahmed Abd Elmaogod, Sahar Aly Daoud, Zahraa Mohammed Mostafa, Ebtehal Mohamed Mostafa Mahmoud   +3 more
doaj   +1 more source

Predicting drug response of tumors from integrated genomic profiles by deep neural networks

, 2018
The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insights into the oncogenic features modulating drug response.
Chen, Hung-I Harry, Chen, Yidong, Chiu, Yu-Chiao, Gorthi, Aparna, Huang, Yufei, Wang, Li-Ju, Zhang, Songyao, Zhang, Tinghe   +7 more
core   +1 more source

Nanoplatform‐Enabled Genetic Interventions for Central Nervous System Disorders: Advances in Delivery Strategies and Therapeutic Potential

Advanced Genetics, EarlyView.
This review provides a detailed description of gene mutations and epigenetic mechanisms in central nervous system (CNS) disease, strategies for gene therapy, challenges for CNS gene therapy and gene‐drug nanocarriers. This review also summarizes the applications of nanogenetic therapy platforms in CNS diseases (brain tumors, neurodegenerative diseases,
Fuming Liang, Shizhen Cui, Jing Yang, Zhaohui He, Ling Zhu   +4 more
wiley   +1 more source

IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing

World Journal of Surgical Oncology, 2017
Background Isocitrate dehydrogenase 1 (IDH1) mutation is common in low-grade glioma (approximately 80%) and acute myeloid leukemia (approximately 10%).
Jung Hee Lee, Dong Hoon Shin, Won Young Park, Nari Shin, Ahrong Kim, Hyun Jung Lee, Young Keum Kim, Kyung Un Choi, Jee Yeon Kim, Young Il Yang, Chang Hun Lee, Mee Young Sol   +11 more
doaj   +1 more source

Idh1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis [PDF]

, 2018
Introduction The gene encoding isocitrate dehydrogenase 1 (IDH1) is frequently mutated in several tumor types including gliomas. The most prevalent mutation in gliomas is a missense mutation leading to a substitution of arginine with histidine at the ...
De Wit, M. (Maurice), French, P.J. (Pim), Gao, Y. (Ya), Lamfers, M.L.M. (Martine), Linde, H.C. (Herma) van der, Salomons, G.S. (Gajja), Sillevis Smitt, P.A.E. (Peter), Struys, E. (E.), Willemsen, R. (Rob)   +8 more
core   +1 more source

Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma.

Journal of Clinical Oncology, 2020
PURPOSE Surgery is the primary therapy for localized chondrosarcoma; for locally advanced and/or metastatic disease, no known effective systemic therapy exists.
W. Tap, V. Villalobos, G. Cote, H. Burris, F. Janku, O. Mir, M. Beeram, A. Wagner, Liewen Jiang, Bin Wu, S. Choe, K. Yen, C. Gliser, Bin Fan, S. Agresta, S. Pandya, J. Trent   +16 more
semanticscholar   +1 more source