Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas. [PDF]
, 2019 PurposeGlioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for ...
Kaprealian, Tania +6 more
core
The hypermethylation of the O6‐methylguanine‐DNA methyltransferase gene promoter in gliomas—correlation with array comparative genome hybridization results and IDH1 mutation [PDF]
, 2011 Katja Tuononen +10 more
openalex +1 more source
Insights Into Macrophage Ferroptosis: Implications for Atherosclerosis
Cell Proliferation, EarlyView.Macrophage ferroptosis drives atherosclerosis by enhancing oxidative stress and inflammation, accelerating plaque progression and instability. Targeting macrophage ferroptosis presents a promising therapeutic strategy for atherosclerosis treatment.
Xiehui Chen, Xiangbo Liu, Changchun Zeng
wiley +1 more source
Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression
Cell Death and DiseaseIsochlorate dehydrogenase 1 (IDH1) is an important metabolic enzyme for the production of α-ketoglutarate (α-KG), which has antitumor effects and is considered to have potential antitumor effects.
Zhao Cui +7 more
doaj +1 more source
Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. [PDF]
, 2017 Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenvironment. Here we illustrate how such conditions promote chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Glucose or glutamine withdrawal
Blanco, Fernando F +18 more
core +1 more source
MPTH-02MOLECULAR CLASSIFICATION BASED ON IDH1/2 AND TERT PROMOTER WELL-DEFINES SUBGROUPS WITH DIFFERENT OUTCOME IN ADULT DIFFUSE GLIOMAS: A REPORT FROM GLIOMA MOLECULAR CLASSIFICATION CONSORTIUM [PDF]
, 2015 Hideyuki Arita +19 more
openalex +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Therapeutic options for newly diagnosed (ND) acute myeloid leukemia (AML) have increased in recent years, leading to a shift in the treatment paradigm from conventional, intensive chemotherapy toward targeted and less intensive therapy. Since 2017, there has been a surge in FDA approvals for novel therapies, including small molecule inhibitors
Thuy N. Ho +6 more
wiley +1 more source
Histopathology, EarlyView.Assessment of twenty testicular AGCTs with two different next‐generation sequencing (NGS) panels reveals differences with ovarian AGCTs, including absence of hotspot FOXL2 variants. Aims Testicular adult granulosa cell tumours (AGCTs) are rare and show several clinical–pathological differences with their ovarian counterparts.
Costantino Ricci +20 more
wiley +1 more source