Results 121 to 130 of about 34,512 (245)

The hypermethylation of the O⁶‐methylguanine‐DNA methyltransferase gene promoter in gliomas—correlation with array comparative genome hybridization results and IDH1 mutation [PDF]

, 2011
Katja Tuononen, Olli Tynninen, Virinder Kaur Sarhadi, A. Tyybäkinoja, Mikael Lindlöf, Miia Antikainen, Juha Näpänkangas, Ari Hirvonen, Hanna Mäenpää, Anders Paetau, Sakari Knuutila   +10 more
openalex   +1 more source

Multiple Genomic Technologies Validate Rare Novel Variant and Direct Medical Care in Vascular Anomalies

American Journal of Medical Genetics Part A, Volume 197, Issue 11, November 2025.
ABSTRACT Some vascular anomalies, such as hamartomas associated with PTEN hamartoma tumor syndrome (PHTS) and fibroadipose vascular anomaly (FAVA, often due to PI3KCA variants), share similar clinical, radiological, and histopathological presentations that challenge clinicians to provide an accurate diagnosis.
Luciana Daniela Garlisi Torales, Kristina Woodis, Allison Britt, Lea F. Surrey, Abhay Srinivasan, Arupa Ganguly, Maria Limmina, Dong Li, Suzanne P. MacFarland, Denise M. Adams, Sarah E. Sheppard   +10 more
wiley   +1 more source

Value and Limitations of Immunohistochemistry and Gene Sequencing for Detection of theIDH1-R132HMutation in Diffuse Glioma Biopsy Specimens [PDF]

, 2011
Matthias Preusser, Adelheid Wöhrer, Susanne Stary, Romana Höftberger, Berthold Streubel, Johannes A. Hainfellner   +5 more
openalex   +1 more source

Ivosidenib and Azacitidine in IDH1 -Mutated AML

New England Journal of Medicine, 2022
Goodman, Aaron M, Mohyuddin, Ghulam Rehman, Prasad, Vinay   +2 more
openaire   +6 more sources

Magnetic Resonance Spectroscopy of 2‐Hydroxyglutarate and Glycine in Adult Subjects With Brainstem Gliomas

NMR in Biomedicine, Volume 38, Issue 11, November 2025.
MRS of 2‐hydroxyglutarate (2HG) and glycine in 19 patients with brainstem tumors is reported. TE 97ms PRESS was obtained at 3T and LCModel was used for spectral fitting. Tumors with elevated 2HG and undetectable 2HG were clearly distinguishable. Tumors with elevated glycine showed rapid progression.
Vivek Tiwari, Sandeep K. Ganji, Zhongxu An, Marco C. Pinho, Larry T. Davis, Colin D. McKnight, Julia D. Berry, Bret C. Mobley, Leo Y. Luo, Alexander C. Mohler, Ryan T. Merrell, Patrick D. Kelly, Reid C. Thompson, Bruce E. Mickey, Craig R. Malloy, John C. Gore, Toral R. Patel, Elizabeth A. Maher, Changho Choi   +18 more
wiley   +1 more source

Hippo pathway effectors are associated with glioma patient survival, control cell proliferation and sterol metabolism through TEAD3

Brain Pathology, Volume 35, Issue 6, November 2025.
The Hippo pathway transcription factor TEAD3 represents an independent prognostic biomarker of tumor recurrence and a potential therapeutic vulnerability through its regulation of cholesterol metabolism in glioma. Abstract Glioblastomas represent the most common and lethal primary brain tumors in the world.
Konstantin Masliantsev, Amandine Desette, Anne‐Alicia Gonzalez, Inès Garrouche, Anaïs Noblanc, Maleaume Soulard, Mathis Triquard, Serge Milin, Michel Wager, Lucie Karayan‐Tapon, Pierre‐Olivier Guichet   +10 more
wiley   +1 more source

Diagnosis and treatment of occipital brain lesions in children

Developmental Medicine &Child Neurology, Volume 67, Issue 11, Page 1409-1420, November 2025.
Occipital brain lesions in children represent a diagnostic challenge due to the large spectrum of etiologies and overlapping clinical features. This review analyses common and less common causes of occipital brain lesions in children, including malformative, vascular, genetic/metabolic, infectious, inflammatory, and neoplastic conditions.
Luca Bartolini, Giulia Savoca, Matteo Tassone, Tiziana Metitieri, Renzo Guerrini   +4 more
wiley   +1 more source

IDH1/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom [PDF]

, 2012
Florian Stockhammer, Martin Misch, Hans-Joachim Helms, Ulrike Lengler, Friedrich Prall, Andreas von Deimling, Christian Hartmann   +6 more
openalex   +1 more source

Constructing a Model Using Clock‐Related lncRNAs for Predicting the Tumor Microenvironment of Gliomas

Brain and Behavior, Volume 15, Issue 10, October 2025.
Step 1: Identify hub clock‐related genes through differential expression analysis, univariate Cox analysis, and LASSO‐Cox regression; Step 2: Identify and screen hub clock‐related lncRNAs using correlation analysis and LASSO‐Cox regression; Step 3: Validate the expression differences of the selected lncRNAs in cell experiments using qPCR.
Mingjie Gong, Chengfa Sun, Zhenhua Shi, Junxiang Wang, Weiwei Zhai, Zhengquan Yu   +5 more
wiley   +1 more source

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function [PDF]

, 2012
Masato Sasaki, Christiane B. Knobbe‐Thomsen, Momoe Itsumi, Andrew Elia, Isaac S. Harris, Iok In Christine Chio, Rob A. Cairns, Susan McCracken, Andrew Wakeham, Jillian Haight, Annick You Ten, Bryan E. Snow, Takeshi Ueda, Satoshi Inoue, Kazuo Yamamoto, Myunggon Ko, Anjana Rao, Katharine Yen, Shinsan M. Su, Tak W. Mak   +19 more
openalex   +1 more source