Results 131 to 140 of about 35,587 (246)

MPTH-02MOLECULAR CLASSIFICATION BASED ON IDH1/2 AND TERT PROMOTER WELL-DEFINES SUBGROUPS WITH DIFFERENT OUTCOME IN ADULT DIFFUSE GLIOMAS: A REPORT FROM GLIOMA MOLECULAR CLASSIFICATION CONSORTIUM [PDF]

, 2015
Hideyuki Arita, Kai Yamasaki, Yuko Matsushita, Taishi Nakamura, Mitsuaki Shirahata, Kaoru Tamura, Yuzo Terakawa, Junya Fukai, Akitake Mukasa, Hiroyoshi Suzuki, Makoto Shibuya, Yonehiro Kanemura, Toshiki Yoshimine, Nobuhito Saito, Motoo Nagane, Keisuke Ueki, Takashi Komori, Ryo Nishikawa, Yoshitaka Narita, Koichi Ichimura   +19 more
openalex   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

Evaluation of the rapid Idylla IDH1-2 mutation assay in FFPE glioma samples

Diagnostic Pathology
IDH1 and IDH2 mutational status is a critical biomarker with diagnostic, prognostic, and treatment implications in glioma. Although IDH1 p.R132H-specific immunohistochemistry is available, it is unable to identify other mutations in IDH1/2.
James P. Solomon, Carlos Munoz-Zuluaga, Cheyanne Slocum, Alicia Dillard, Lin Cong, Jiajing Wang, Neal Lindeman, Michael Kluk, Benjamin Liechty, David Pisapia, Hanna Rennert, Priya D. Velu   +11 more
doaj   +1 more source

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

Supplementary Figures 1 - 6 from IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

, 2023
Alexandra Grassian, Seth J. Parker, Shawn M. Davidson, Ajit S. Divakaruni, Courtney R. Green, Xiamei Zhang, Kelly L. Slocum, Minying Pu, Fallon Lin, Chad Vickers, Carol Joud-Caldwell, Franklin Chung, Hong Yin, Erika D. Handly, Christopher Straub, Joseph D. Growney, Matthew G. Vander Heiden, Anne N. Murphy, Raymond Pagliarini, Christian M. Metallo   +19 more
openalex   +1 more source

Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer metabolic reprogramming is a key hallmark of tumorigenesis and antitumor immunity. It boosts tumor progression by enhancing cancer cell fitness in hostile microenvironments and facilitates immune evasion by evading natural and therapy‐driven antitumor immune responses.
Tong Zhang, Ping Gao, Linchong Sun
wiley   +1 more source

Supplementary Figure S5 from Radioprotection of <i>IDH1</i>-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198

, 2023
Remco J. Molenaar, Dennis Botman, Myrthe A. Smits, Vashendriya V. Hira, Sanne A. van Lith, Jan Stap, Peter Henneman, Mohammed Khurshed, Krissie Lenting, Adri N. Mul, Dionysia Dimitrakopoulou, Cornelis M. van Drunen, Ron A. Hoebe, Tomas Radivoyevitch, Johanna W. Wilmink, Jaroslaw P. Maciejewski, W. Peter Vandertop, William P. J. Leenders, Fonnet E. Bleeker, Cornelis J.F. Van Noorden   +19 more
openalex   +1 more source

Senescent Fibroblasts Drive Melanoma Progression Through GCP‐2 Induced CREB Phosphorylation Enhancing Glycolysis

Aging Cell, Volume 24, Issue 12, December 2025.
Aging constitutes the largest risk factor for melanoma progression; the underlying reason is poorly understood. Here we show that the chemokine GCP‐2 is excessively released by senescent fibroblasts in vitro and in the skin of old melanoma patients. GCP‐2, via phosphorylation of the transcription factor CREB at serine 133, regulates cell cycle control ...
Abhijit Basu, Vida Farsam, Karmveer Singh, Diana Crisan, Nicolai Treiber, Lars Alexander Schneider, Margit Huber, Jennifer I. Engelmeyer, Björn Schumacher, Pallab Maity, Daniel Brandt, Martin Jastroch, Cornelia Mauch, Hartmut Geiger, Dimitris Kletsas, Karin Scharffetter‐Kochanek   +15 more
wiley   +1 more source

Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma [PDF]

, 2020
Victor Ruiz‐Rodado, Tomohiro Seki, Tyrone Dowdy, Adrian Lita, Meili Zhang, Sue Han, Chunzhang Yang, Murali Cherukuri, Mark R. Gilbert, Mioara Larion   +9 more
openalex   +1 more source

Telomerase Depletion Accelerates Ageing of the Zebrafish Brain

Aging Cell, Volume 24, Issue 12, December 2025.
Telomerase depletion accelerates markers of ageing in the zebrafish brain, ranging from dysregulated immune and stress ageing transcriptomic hallmarks to in situ accumulation of senescence‐associated markers and inflammation, dysfunction of the blood–brain barrier and increased anxiety behaviour.
Raquel R. Martins, Savandara Besse, Pam S. Ellis, Rabia Sevil, Naomi Hartopp, Catherine Purse, Georgia Everett‐Brown, Owain Evans, Nadiyah Mughal, Mina H. F. Wahib, Zerkif Yazigan, Samir Morsli, Ada Jimenez‐Gonzalez, Andrew Grierson, Heather Mortiboys, Chrissy Hammond, Michael Rera, Catarina M. Henriques   +17 more
wiley   +1 more source