Results 131 to 140 of about 63,359 (335)

Mutational status of IDH1 in uveal melanoma

Experimental and Molecular Pathology, 2016
Uveal (intraocular) melanoma is an uncommon malignancy that comprises a small percentage of all melanoma cases. While many uveal melanomas harbor mutations in the BRCA-Associated Protein 1 (BAP1) gene, the genetics of non-BAP1 associated tumors are not completely understood.
Patrick J. Cimino, Yungtai Kung, Joshua I. Warrick, Shu-Hong Chang, C. Dirk Keene   +4 more
openaire   +3 more sources

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

IDH1/2 Mutants Inhibit TET-Promoted Oxidation of RNA 5mC to 5hmC. [PDF]

PLoS ONE, 2016
TETs (TET1/2/3) play critical roles in multi cellular processes through DNA demethylation driven by oxidation of DNA 5mdC to 5hmdC. Interestingly, recent studies indicated that TETs also oxidate RNA 5mC to 5hmC.
Qiang Xu, Kai Wang, Lina Wang, Yuting Zhu, Guangyu Zhou, Dan Xie, Qingkai Yang   +6 more
doaj   +1 more source

A case of recurrent epilepsy-associated rosette-forming glioneuronal tumor with anaplastic transformation in the absence of therapy. [PDF]

, 2019
Rosette-forming glioneuronal tumor (RGNT) most commonly occurs adjacent to the fourth ventricle and therefore rarely presents with epilepsy. Recent reports describe RGNT occurrence in other anatomical locations with considerable morphologic and genetic ...
Corless, Christopher L, Ferris, Sean P, Grafe, Marjorie, Gultekin, Sakir H, Halfpenny, Aaron, Lawce, Helen, Lucas, Lora, Moore, Stephen, Nazemi, Kellie, Olson, Susan, Perry, Arie, Selden, Nathan, Solomon, David A, Woltjer, Randy, Wood, Matthew D   +14 more
core   +1 more source

Imaging‐Based Molecular Characterization of Adult‐Type Diffuse Glioma Using Diffusion and Perfusion MRI in Pre‐ and Post‐Treatment Stage Considering Spatial and Temporal Heterogeneity

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Imaging‐based molecular characterization is important for identifying treatment targets in adult‐type diffuse gliomas. Purpose To assess isocitrate dehydrogenase (IDH) mutation and epidermal growth factor receptor (EGFR) amplification status in primary and recurrent gliomas using diffusion and perfusion MRI, addressing spatial and ...
Yun Hwa Roh, E‐Nae Cheong, Ji Eun Park, Yangsean Choi, Seung Chai Jung, Sang Woo Song, Young‐Hoon Kim, Chang‐Ki Hong, Jeong Hoon Kim, Ho Sung Kim   +9 more
wiley   +1 more source

Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes. [PDF]

, 2014
Molecular stratification of tumors is essential for developing personalized therapies. Although patient stratification strategies have been successful; computational methods to accurately translate the gene-signature from high-throughput platform to a ...
Bi, Yingtao, Davuluri, Ramana V, Macyszyn, Luke, O'Rourke, Donald M, Pal, Sharmistha, Showe, Louise C   +5 more
core   +1 more source

XGBoost Improves Classification of MGMT Promoter Methylation Status in IDH1 Wildtype Glioblastoma

Journal of Personalized Medicine, 2020
Approximately 96% of patients with glioblastomas (GBM) have IDH1 wildtype GBMs, characterized by extremely poor prognosis, partly due to resistance to standard temozolomide treatment.
N. Le, D. Do, Fang-Ying Chiu, E. Yapp, Hui-Yuan Yeh, Cheng-Yu Chen   +5 more
semanticscholar   +1 more source

Optimized Long‐TE 1H sLASER MR Spectroscopic Imaging at 3T for Separate Quantification of Glutamate and Glutamine in Glioma

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Glutamate and glutamine are critical metabolites in gliomas, each serving distinct roles in tumor biology. Separate quantification of these metabolites using in vivo MR spectroscopy (MRS) at clinical field strengths (≤ 3T) is hindered by their molecular similarity, resulting in overlapping, hence indistinguishable, spectral peaks ...
Seyma Alcicek, Michael W. Ronellenfitsch, Joachim P. Steinbach, Andrei Manzhurtsev, Dennis C. Thomas, Katharina J. Weber, Vincent Prinz, Marie‐Thérèse Forster, Elke Hattingen, Ulrich Pilatus, Katharina J. Wenger   +10 more
wiley   +1 more source

IDH1: function follows form [PDF]

Science-Business eXchange, 2009
Researchers at Agios Pharmaceuticals have shown that a common cancer-associated mutation causes the enzyme IDH1 to acquire a new catalytic activity while stripping it of its native one. The biotech is exploring the therapeutic potential of its discovery in gliomas and secondary glioblastomas.
openaire   +2 more sources

Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer

The Journal of Pathology, EarlyView.
Abstract The CpG island methylator phenotype (CIMP) occurs in many colorectal cancers (CRCs). CIMP is closely associated with global hypermethylation and tends to occur in proximal tumours with microsatellite instability (MSI), but its origins have been obscure.
Joseph C Ward, Melissa Morgan, James Wood, Connor Woolley, Albert Antao Nobre de Menezes, Alina Finch, Kitty Sherwood, Qiwen Huang, Chloe S Henry, Juan Fernández‐Tajes, Ignacio Soriano, Steve Thorn, Isabelle Legge, James McCullagh, David Kerr, Rachel Kerr, Rahul K Hejmadi, Mark J Arends, The S:CORT Consortium, Richard Adams, Simon Bach, Andrew Beggs, Louise Brown, Francesca Buffa, Jean‐Baptiste Cazier, Enric Domingo, Andrew Blake, Che‐Hsi Wu, Ekaterina Chatzpili, Susan Richman, Philip Dunne, Paul Harkin, Geoff Higgins, Jim Hill, Chris Holmes, Denis Horgan, Rick Kaplan, Richard Kennedy, Mark Lawler, Simon Leedham, Ultan McDermott, Gillies McKenna, Gary Middleton, Dion Morton, Graeme Murray, Philip Quirke, Manuel Salto‐Tellez, Les Samuel, Anna Schuh, David Sebag‐Montefiore, Matt Seymour, Ricky Sharma, Richard Sullivan, Ian Tomlinson, Nicholas West, Richard Wilson, Enric Domingo, Timothy Maughan, Chiara Bardella, Ian Tomlinson   +59 more
wiley   +1 more source