Results 141 to 150 of about 63,359 (335)

Glioblastoma multiforme with transdural extension to the external auditory canal via the tegmen tympani—Clinical report with review of the literature

Eye &ENT Research, EarlyView.
Arba Cecia, Emal Lesha, David G. Laird, Elsa Nico, Kaan Yagmurlu, Bruce L. Fetterman, L. Madison Michael II   +6 more
wiley   +1 more source

Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function

PM&R, EarlyView.
Abstract Background Determining appropriate suitability and goals for inpatient rehabilitation of patients with glioblastoma, isocitrate dehydrogenase‐wildtype (GBM) requires real‐time prognostic information. Functional measures, such as bed mobility, are standardized scores that can be assessed by members of the care team at the bedside and may aid ...
Tomasz Gruchala, Christopher W. Lewis, Kathryn Abplanalp, Prakash Jayabalan, Theresa L. Walunas, Jodi L. Johnson, Derek A. Wainwright, Rimas V. Lukas, Gayle Spill, Ishan Roy   +9 more
wiley   +1 more source

The role of EGFR double minutes in modulating the response of malignant gliomas to radiotherapy. [PDF]

, 2017
EGFR amplification in cells having double minute chromosomes (DM) is commonly found in glioblastoma multiforme (GBM); however, how much it contributes to the current failure to treat GBM successfully is unknown.
Atkin, Naomi, Chen, Yumay, Gau, Alex, Giedzinski, Erich, Hu, Yuanjie, Lee, Nathan, Limoli, Charles, Linskey, Mark E, Ly, Khang Chi, Pan, Francine, Qiao, Jiao, Ru, Ning, Siegel, Eric R, Tran, Katherine, Wang, Ping, Yu, Liping, Zhou, Yi-Hong   +16 more
core   +1 more source

SIRT2‐dependent IDH1 deacetylation inhibits colorectal cancer and liver metastases

EMBO Reports, 2020
Protein lysine acetylation affects colorectal cancer (CRC) distant metastasis through multiple pathways. In a previous proteomics screen, we found that isocitrate dehydrogenase 1 (IDH1) is hyperacetylated in CRC primary tumors and liver metastases. Here,
Bo Wang, Y. Ye, Xin Yang, Boya Liu, Zhe Wang, Shuaiyi Chen, K. Jiang, Wei Zhang, Hongpeng Jiang, H. Mustonen, P. Puolakkainen, Shan Wang, Jianyuan Luo, Zhanlong Shen   +13 more
semanticscholar   +1 more source

Bridging the Gap: How Organ‐on‐a‐Chip Technology Facilitates the Battle against Glioma

Small Science, EarlyView.
This review critically evaluates current state‐of‐the‐art in vitro glioma models especially glioma‐on‐a‐chip models based on readout capability, performance, and physiological relevance. It summarizes the key parameters and proposes a practical framework to guide researchers in selecting the most suitable preclinical models for glioma studies.
Su Liu, Zhenyu Gong, Dairan Zhou, Vanesa Ayala‐Nunez, Tao Xu, Peter Wick   +5 more
wiley   +1 more source

Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression

Cell Death and Disease
Isochlorate dehydrogenase 1 (IDH1) is an important metabolic enzyme for the production of α-ketoglutarate (α-KG), which has antitumor effects and is considered to have potential antitumor effects.
Zhao Cui, Caifeng Li, Wei Liu, Mo Sun, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen   +7 more
doaj   +1 more source

Persistent IDH1/2 mutations in remission can predict relapse in patients with acute myeloid leukemia

Haematologica, 2019
Persistence of IDH1 or IDH2 mutations in remission bone marrow specimens of patients with acute myeloid leukemia has been observed, but the clinical impact of these mutations is not well known.
Chi Young Ok, Sanam Loghavi, Dawen Sui, Peng Wei, Rashmi Kanagal-Shamanna, C. Cameron Yin, Zhuang Zuo, Mark J. Routbort, Guilin Tang, Zhenya Tang, Jeffrey L. Jorgensen, Rajyalakshmi Luthra, Farhad Ravandi, Hagop M. Kantarjian, Courtney D. DiNardo, L. Jeffrey Medeiros, Sa A. Wang, Keyur P. Patel   +17 more
doaj   +1 more source

Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia [PDF]

, 2017
Acute Myeloid Leukaemia (AML) develops when there is a block in differentiation and uncontrolled proliferation of myeloid precursors, resulting in bone marrow failure.
Gibson, Brenda E.S., Harrison, Christine J., Keeshan, Karen, Laing, Alison A.   +3 more
core   +1 more source

Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia.

Blood, 2019
Ivosidenib (AG-120) is an oral, targeted agent that suppresses production of the oncometabolite 2-hydroxyglutarate via inhibition of the mutant isocitrate dehydrogenase 1 (mIDH1) enzyme.
G. Roboz, C. Dinardo, E. Stein, S. de Botton, A. Mims, G. Prince, J. Altman, M. Arellano, W. Donnellan, H. Erba, G. Mannis, D. Pollyea, A. Stein, G. Uy, J. Watts, A. Fathi, H. Kantarjian, M. Tallman, S. Choe, D. Dai, Bin Fan, Hongfang Wang, V. Zhang, K. Yen, S. Kapsalis, D. Hickman, Hua Liu, S. Agresta, Bin Wu, E. Attar, R. Stone   +30 more
semanticscholar   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source