Journal of Applied Clinical Medical Physics, Volume 27, Issue 1, January 2026.Abstract Background In cancer radiotherapy, radiation‐induced lymphopenia (RIL) has been reported to be correlated with adverse clinical outcomes such as reduced locoregional control (LRC), distant‐metastasis‐free survival (DMFS), and overall survival (OS) in various treatment sites.
Sebastian Tattenberg +5 more
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Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling [PDF]
Chunxia Shi +5 more
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Multi‐Omics Integration for Advancing Glioma Precision Medicine
Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 4-13, January 2026.ABSTRACT Gliomas are among the most malignant and aggressive tumors of the central nervous system, characterized by the absence of early diagnostic markers, poor prognosis, and a lack of effective treatments. Advances in high‐throughput technologies have facilitated a refined molecular classification of gliomas, incorporating genetic features. However,
Maria Guarnaccia +4 more
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Equivalences of (co)module algebra structures over Hopf algebras
, 2020 We introduce the notion of support equivalence for (co)module algebras (over Hopf algebras), which generalizes in a natural way (weak) equivalence of gradings. We show that for each equivalence class of (co)module algebra structures on a given algebra A,
Agore, Ana +2 more
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Ivosidenib for IDH1‐Mutant Intrahepatic Cholangiocarcinoma: Insights From a Multicenter Real‐World Study [PDF]
Monica Niger +28 more
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Patterns of Tumor Contrast Enhancement Predict the Prognosis of Anaplastic Gliomas withIDH1Mutation [PDF]
, 2015 Yinyan Wang +6 more
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Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models [PDF]
, 2022 Hans-Juergen Schulten +10 more
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PRC2‐Related Epigenetic Age Acceleration in Acute Myeloid Leukemia with DNMT3A and IDH2 Mutations
Advanced Biology, Volume 10, Issue 1, January 2026.This study reveals causality‑enriched epigenetic clocks offer additional insight into acute myeloid leukemia (AML) specific DNA methylation remodeling, particularly when integrated with genetic stratification, like DNMT3A or IDH2 mutations. AdaptAge showed subgroup‑specific associations with survival and appeared responsive to treatment‑related changes,
Zhengyi Yan +4 more
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Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma
Advanced Science, Volume 13, Issue 3, 14 January 2026.IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang +16 more
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