Results 171 to 180 of about 63,359 (335)
European Journal of Haematology, EarlyView.ABSTRACT The evolution of acute myeloid leukemia (AML) classifications has progressively shifted the diagnostic focus toward genetic criteria. Nevertheless, morphology remains a key element in clinical practice, often serving as the initial trigger for additional molecular investigations. The diagnosis of acute erythroleukemia (AEML), initially defined
Laurène Fenwarth +23 more
wiley +1 more source
IDH1 Gene Mutations: A New Paradigm in Glioma Prognosis and Therapy? [PDF]
, 2010 Marianne Labussière +3 more
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich +9 more
wiley +1 more source
IDH1 mutant structures reveal a mechanism of dominant inhibition [PDF]
, 2010 Shimin Zhao, Kun‐Liang Guan
openalex +1 more source
American Journal of Hematology, Volume 100, Issue 7, Page 1163-1172, July 2025.ABSTRACT How to select the appropriate intensity of chemotherapy in older adults with acute myeloid leukemia (AML) remains an unanswered question. In a phase II trial of older adults ≥ 60 years with AML (n = 73), we used geriatric assessment (measures of comorbidity burden, physical and cognitive function) to determine fitness for intensive ...
Vijaya R. Bhatt +10 more
wiley +1 more source
IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming
eLifeIsocitrate dehydrogenase 1 (IDH1) is the key enzyme that can modulate cellular metabolism, epigenetic modification, and redox homeostasis. Gain-of-function mutations and decreased expression of IDH1 have been demonstrated to be associated with ...
Mengjia Li +11 more
doaj +1 more source
Mutant IDH1 Confers an in Vivo Growth in a Melanoma Cell Line with BRAF Mutation [PDF]
, 2011 Tatsuhiro Shibata +4 more
openalex +1 more source
American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.ABSTRACT Hereditary multiple osteochondromas (HMO) is an autosomal dominant disorder caused by heterozygous deleterious variants in the EXT1 or EXT2 genes. While the clinical core phenotype is well established and mainly consists of bone deformities, limb length discrepancies, multiple benign bone neoplasms, and increased risk of chondrosarcoma, the ...
Francesco Comisi +7 more
wiley +1 more source
Cell Reports, 2018 Summary: Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate ...
Mehmet G. Badur +8 more
doaj
Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations. [PDF]
, 2019 学位記番号 ...
Murakami, Chiaki +2 more
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